Genomic epidemiology of a national outbreak of post-surgical Mycobacterium abscessus wound infections in Brazil

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dc.citation.issue5
dc.citation.volume3
dc.contributor.authorEverall, Izzy
dc.contributor.authorNogueira, Christiane Lourenco [UNIFESP]
dc.contributor.authorBryant, Josephine M.
dc.contributor.authorSanchez-Buso, Leonor
dc.contributor.authorChimara, Erica
dc.contributor.authorDuarte, Rafael da Silva
dc.contributor.authorRamos, Jesus Pais
dc.contributor.authorBatista Lima, Karla Valeria
dc.contributor.authorLopes, Maria Luiza
dc.contributor.authorPalaci, Moises
dc.contributor.authorKipnis, Andre
dc.contributor.authorMonego, Fernanda
dc.contributor.authorAndres Floto, R.
dc.contributor.authorParkhill, Julian
dc.contributor.authorLeao, Sylvia Cardoso [UNIFESP]
dc.contributor.authorHarris, Simon R.
dc.coverageLondon
dc.date.accessioned2020-07-17T14:02:14Z
dc.date.available2020-07-17T14:02:14Z
dc.date.issued2017
dc.description.abstractAn epidemic of post-surgical wound infections, caused by a non-tuberculous mycobacterium, has been on-going in Brazil. It has been unclear whether one or multiple lineages are responsible and whether their wide geographical distribution across Brazil is due to spread from a single point source or is the result of human-mediated transmission. 188 isolates, collected from nine Brazilian states, were whole genome sequenced and analysed using phylogenetic and comparative genomic approaches. The isolates from Brazil formed a single clade, which was estimated to have emerged in 2003. We observed temporal and geographic structure within the lineage that enabled us to infer the movement of sub-lineages across Brazil. The genome size of the Brazilian lineage was reduced relative to most strains in the three subspecies of Mycobacterium abscessus and contained a novel plasmid, pMAB02, in addition to the previously described pMAB01 plasmid. One lineage, which emerged just prior to the initial outbreak, is responsible for the epidemic of post-surgical wound infections in Brazil. Phylogenetic analysis indicates that multiple transmission events led to its spread. The presence of a novel plasmid and the reduced genome size suggest that the lineage has undergone adaptation to the surgical niche.en
dc.description.affiliationWellcome Trust Sanger Inst, Cambridge, England
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Sao Paulo, Brazil
dc.description.affiliationUniv Cambridge, Dept Med, MRC Lab Mol Biol, Mol Immun Unit, Cambridge, England
dc.description.affiliationAdolfo Lutz Inst, Nucl TB Micobacterioses, Av Dr Arnaldo,666 9o Andar, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Microbiol Prof Paulo Goes, Rio De Janeiro, Brazil
dc.description.affiliationFiocruz MS, Ctr Referencia Prof Helio Fraga, Rio De Janeiro, RJ, Brazil
dc.description.affiliationInst Evandro Chagas, Bacteriol & Mycol Sect, Belem, Para, Brazil
dc.description.affiliationUniv Fed Espirito Santo, Nucl Doencas Infecciosas, Vitoria, ES, Brazil
dc.description.affiliationUniv Fed Goias, Dept Microbiol, Goiania, Go, Brazil
dc.description.affiliationUniv Fed Parana, Dept Med Vet, Curitiba, Parana, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipUK CF Trust (Strategic Research Centre Award)
dc.description.sponsorshipIDWellcome Trust: 098051
dc.description.sponsorshipIDWellcome Trust: 10224/Z/15/Z
dc.description.sponsorshipIDWellcome Trust: 107032AIA
dc.description.sponsorshipIDUK CF Trust (Strategic Research Centre Award): 003
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1099/mgen.0.000111
dc.identifier.citationMicrobial Genomics. London, v. 3, n. 5, p. -, 2017.
dc.identifier.doi10.1099/mgen.0.000111
dc.identifier.fileWOS000431154900001.pdf
dc.identifier.issn2057-5858
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54697
dc.identifier.wosWOS:000431154900001
dc.language.isoeng
dc.publisherMicrobiology Soc
dc.relation.ispartofMicrobial Genomics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMycobacterium abscessusen
dc.subjecttransmissionen
dc.subjectnosocomial infectionsen
dc.subjectoutbreaken
dc.subjectGenomic epidemiologyen
dc.titleGenomic epidemiology of a national outbreak of post-surgical Mycobacterium abscessus wound infections in Brazilen
dc.typeinfo:eu-repo/semantics/article
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