Direct comparison of diagnostic performance of transient elastography in patients with chronic hepatitis B and chronic hepatitis C

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dc.contributor.authorCardoso, Ana-Carolina
dc.contributor.authorCarvalho-Filho, Roberto J. [UNIFESP]
dc.contributor.authorStern, Christiane
dc.contributor.authorDipumpo, Alexandrine
dc.contributor.authorGiuily, Nathalie
dc.contributor.authorRipault, Marie-Pierre
dc.contributor.authorAsselah, Tarik
dc.contributor.authorBoyer, Nathalie
dc.contributor.authorLada, Olivier
dc.contributor.authorCastelnau, Corinne
dc.contributor.authorMartinot-Peignoux, Michelle
dc.contributor.authorValla, Dominique-Charles
dc.contributor.authorBedossa, Pierre
dc.contributor.authorMarcellin, Patrick
dc.contributor.institutionUniv Paris 07
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:05Z
dc.date.available2016-01-24T14:27:05Z
dc.date.issued2012-04-01
dc.description.abstractBackground/ Aims: Accuracy of transient elastography (TE) in hepatitis B virus (HBV) infection has not been well established. We aimed to compare the performances of TE for the assessment of liver fibrosis in patients with chronic HBV or hepatitis C virus (HCV) infection. A secondary analysis was performed to assess whether or not alanine aminotransferase (ALT) levels would impact on the accuracy of TE. Methods: This cross-sectional study, carried out in a single centre, included treatment-naive patients with compensated chronic HBV or HCV infection, consecutively admitted between 2006 and 2008 for a liver biopsy and TE measurement on the same day. Results: A total of 202 HBV patients and 363 HCV subjects were evaluated. Overall diagnostic accuracy of TE in the HBV group was comparable to that observed in HCV patients [area under the receiver-operating characteristics (AUROCs) 0.867 +/-0.026 vs. 0.868 +/-0.019 for predicting F +/-2, P = 0.975; 0.902 +/-0.029 vs. 0.894 +/-0.020 for F +/-3, P = 0.820; and 0.935 +/-0.024 vs. 0.947 +/-0.027 for F4, P = 0.740 respectively]. TE exhibited comparable accuracies, sensitivities, specificities, predictive values and likelihood ratios in HBV and HCV groups. AUROC analysis showed no influence of ALT levels on the performance of TE in HBV individuals. ALT-specific cut-off values did not exhibit significantly higher diagnostic performances for predicting fibrosis in HBV patients with elevated ALT. Conclusions: in HBV patients, TE measurement accurately predicts the absence or presence of significant fibrosis, advanced fibrosis or cirrhosis and shows similar performances as compared to HCV patients. the use of TE cut-off values adjusted to ALT level did not improve performances for estimating liver fibrosis in HBV patients.en
dc.description.affiliationUniv Paris 07, Serv Hepatol, Hop Beaujon, F-92110 Clichy, France
dc.description.affiliationUniv Paris 07, Hop Beaujon, APHP, INSERM U773 CRB3, F-92110 Clichy, France
dc.description.affiliationUniversidade Federal de São Paulo, Hosp São Paulo, Hepatitis Sect, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUniv Paris 07, Serv Anatomopathol, Hop Beaujon, F-92110 Clichy, France
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Hosp São Paulo, Hepatitis Sect, Div Gastroenterol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipRoche
dc.description.sponsorshipMSD
dc.description.sponsorshipGilead
dc.format.extent612-621
dc.identifierhttp://dx.doi.org/10.1111/j.1478-3231.2011.02660.x
dc.identifier.citationLiver International. Malden: Wiley-Blackwell, v. 32, n. 4, p. 612-621, 2012.
dc.identifier.doi10.1111/j.1478-3231.2011.02660.x
dc.identifier.issn1478-3223
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34777
dc.identifier.wosWOS:000301233800013
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofLiver International
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectcirrhosisen
dc.subjecthepatitis Ben
dc.subjecthepatitis Cen
dc.subjectliver fibrosisen
dc.subjectliver stiffnessen
dc.subjecttransient elastographyen
dc.titleDirect comparison of diagnostic performance of transient elastography in patients with chronic hepatitis B and chronic hepatitis Cen
dc.typeinfo:eu-repo/semantics/article
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