Adipose Derived Cells and Tissues for Regenerative Medicine

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dc.contributor.authorGimble, Jeffrey M.
dc.contributor.authorRay, Stephen P.
dc.contributor.authorZanata, Fabiana [UNIFESP]
dc.contributor.authorWu, Xiying
dc.contributor.authorWade, James
dc.contributor.authorKhoobehi, Kamran
dc.contributor.authorFerreira, Lydia Masako [UNIFESP]
dc.contributor.authorBunnell, Bruce A.
dc.date.accessioned2019-08-19T11:50:00Z
dc.date.available2019-08-19T11:50:00Z
dc.date.issued2017
dc.description.abstractAdipose tissue is now recognized as a complex organ serving endocrine, immune, and metabolic functions. Adipose depots are composed of mature adipocytes as well as stromal vascular fraction (SVF) cells, a heterogeneous population of B and T lymphocytes, endothelial cells, macrophages, pericytes, smooth muscle, and stromal cells that can be isolated by enzymatic digestion. When placed into culture medium, a subset of the SVF cells can adhere to the plastic surface and expand in number. This latter population, known as "adipose-derived stromal/stem cells" (ASC), exhibits trilineage (adipo-, chondro-, osteo-) differentiation potential. There are currently more than 180 clinical studies underway worldwide exploring the regenerative medical application of SVF cells and ASC in a range of medical conditions. Plastic surgeons have a particular interest in the use of autologous fat and SVF enhanced fat for cosmetic and reconstructive surgical procedures. Orthopedic and craniofacial surgeons have begun to use ASC to treat bone and musculoskeletal defects with success. Furthermore, studies are underway to exploit the immunomodulatory function of ASC to treat immune-mediated disorders such as Crohn's disease. Indeed, it is postulated that adipose tissue and cells modulate tissue regeneration and inflammatory responses through their secretion of paracrine factors. Continued advances in this emerging field will require harmonization of international standards and guidelines defining the release criteria as well as the safety and efficacy of adipose-derived cells and tissues. Currently, there are no accepted standard guidelines for autologous fat harvesting technique, processing, or method of injection. Close collaboration between academia, industry, and regulatory authorities will be necessary to ensure that adipose-derived products are affordable and quality controlled throughout the globe.en
dc.description.affiliationTulane Univ, Sch Med, Ctr Stem Cell Res & Regenerat Med, 1430 Tulane Ave, New Orleans, LA 70112 USA
dc.description.affiliationTulane Univ, Sch Med, Dept Med, New Orleans, LA 70112 USA
dc.description.affiliationTulane Univ, Sch Med, Dept Struct & Cellular Biol, 1430 Tulane Ave, New Orleans, LA 70112 USA
dc.description.affiliationTulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA
dc.description.affiliationLaCell LLC, New Orleans, LA 70112 USA
dc.description.affiliationMidwestern Reg Med Ctr, Canc Treatment Ctr, Zion, IL 60099 USA
dc.description.affiliationUniv Fed São Paulo, BR-04021001 São Paulo, Brazil
dc.description.affiliationPlast Surg Consultants, Baton Rouge, LA 70808 USA
dc.description.affiliationKhoobehi & Associates, Metairie, LA 70002 USA
dc.description.affiliationTulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA
dc.description.affiliationTulane Natl Primate Res Ctr, Covington, LA 70433 USA
dc.description.affiliationUnifespUniv Fed São Paulo, EPM, BR-04021001 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCAPES, Brazil
dc.description.sponsorshipIDCAPES: BEX 1524/15-1
dc.format.extent1477-1482
dc.identifierhttp://dx.doi.org/10.1021/acsbiomaterials.6b00261
dc.identifier.citationAcs Biomaterials Science & Engineering. Washington, v. 3, n. 8, p. 1477-1482, 2017.
dc.identifier.doi10.1021/acsbiomaterials.6b00261
dc.identifier.issn2373-9878
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51452
dc.identifier.wosWOS:000407874600003
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectadipose-derived stromal/stem cellsen
dc.subjectcell therapyen
dc.subjectlipoaspirateen
dc.subjectregenerative medicineen
dc.subjectstromal vascular fraction cellsen
dc.titleAdipose Derived Cells and Tissues for Regenerative Medicineen
dc.typeinfo:eu-repo/semantics/review
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