Soybean and fish oil mixture increases IL-10, protects against DNA damage and decreases colonic inflammation in rats with dextran sulfate sodium (DSS) colitis

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dc.contributor.authorBarros, Karina Vieira de [UNIFESP]
dc.contributor.authorXavier, Roberta Araújo Navarro [UNIFESP]
dc.contributor.authorAbreu, Gilclay Gomes de [UNIFESP]
dc.contributor.authorMartinez, Carlos Augusto Real
dc.contributor.authorRibeiro, Marcelo Lima
dc.contributor.authorGambero, Alessandra
dc.contributor.authorCarvalho, Patricia de Oliveira
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorSilveira, Vera Lucia Flor [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Sao Francisco
dc.date.accessioned2016-01-24T14:05:12Z
dc.date.available2016-01-24T14:05:12Z
dc.date.issued2010-07-08
dc.description.abstractIt was investigated whether dietary polyunsaturated fatty acids (PUFA) could influence colonic injury, tissue DNA damage, cytokines and myeloperoxidase activity (MPO) and plasma corticosterone in DSS-induced colitis rats. Male weaning Wistar rats were fed for 47 days with an AIN-93 diet with control (C), fish (F) or a mixture of fish and soybean oil (SF). the colitis was induced from day 36 until day 42 by 3% DSS in drinking water. On day 48, blood samples were collected for corticosterone determination. the distal colon was excised for histological analysis and to quantify the cytokine (IL-4, IL-10 and INF-gamma), MPO and DNA damage. the disease activity index (DAI) was recorded daily during colitis induction. the DAI, MPO, histological analyses showed decreases only in the SF group compared with the C group. IL-10 was increased and DNA damage was reduced in the groups F and SF, and an inverse correlation between these variables was found. There were no differences in corticosterone, IFN-gamma and IL-4 levels. Soybean and fish oil mixture may be effective in improving colonic injury and DNA damage, and it could be an important complementary therapy in UC to reduce the use of anti-inflammatory drugs and prevent colorectal cancer.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencias Biol, Campus Diadema, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUniv Sao Francisco, Sch Med, Multidisciplinary Res Unit, BR-12900000 Braganca Paulista, SP, Brazil
dc.description.affiliationUniv Sao Francisco, Sch Med, Clin Pharmacol & Gastroenterol Unit, BR-12900000 Braganca Paulista, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencias Biol, Campus Diadema, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.format.extent9
dc.identifierhttps://dx.doi.org/10.1186/1476-511X-9-68
dc.identifier.citationLipids in Health and Disease. London: Biomed Central Ltd, v. 9, 9 p., 2010.
dc.identifier.doi10.1186/1476-511X-9-68
dc.identifier.fileWOS000280405200001.pdf
dc.identifier.issn1476-511X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/32722
dc.identifier.wosWOS:000280405200001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofLipids in Health and Disease
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleSoybean and fish oil mixture increases IL-10, protects against DNA damage and decreases colonic inflammation in rats with dextran sulfate sodium (DSS) colitisen
dc.typeinfo:eu-repo/semantics/article
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