APOA1/A5 Variants and Haplotypes as a Risk Factor for Obesity and Better Lipid Profiles in a Brazilian Elderly Cohort

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dc.contributor.authorChen, Elizabeth Suchi [UNIFESP]
dc.contributor.authorFuruya, Tatiane Katsue [UNIFESP]
dc.contributor.authorMazzotti, Diego Robles [UNIFESP]
dc.contributor.authorOta, Vanessa Kiyomi [UNIFESP]
dc.contributor.authorCendoroglo, Maysa Seabra [UNIFESP]
dc.contributor.authorRamos, Luiz Roberto [UNIFESP]
dc.contributor.authorAraujo, Lara Quirino [UNIFESP]
dc.contributor.authorBurbano, Rommel Rodriguez [UNIFESP]
dc.contributor.authorCardoso Smith, Marilia de Arruda [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:44Z
dc.date.available2016-01-24T13:59:44Z
dc.date.issued2010-06-01
dc.description.abstractGenetic variations in the APOA1/C3/A4/A5 gene cluster have been studied and proposed to be the leading key for susceptibility to cardiovascular diseases and age-associated disorders. We aimed to investigate the associations of rs12721026 (APOA1) and rs1729408 (APOA5) polymorphisms and their haplotypes with some age-related diseases, as well as with lipids and proteins serum levels in a cohort from a Brazilian Elderly Longitudinal Study (EPIDOSO). Genotyping was performed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Statistical analyses were carried out using logistic regression analysis, Student's t-test, and linkage disequilibrium (LD) analysis. Polymorphic allele frequencies were 0.095 and 0.449 for rs12721026 and rs1729408, respectively. the C-allele of rs1729408 was associated with higher high-density lipoprotein (HDL) (P = 0.022) and glycated hemoglobin levels (P = 0.020). We also showed that rs12721026 and rs1729408 were in LD. the GC haplotype, which is composed of the G-allele of rs12721026 and the C-allele of rs1729408, was significantly associated with obesity (P = 0.028), with higher glycated hemoglobin (P = 0.006), and fasting glucose (P = 0.0003) compared to the TT haplotype, which includes the wild-type alleles of both polymorphisms. Moreover, we found an association between the TC haplotype and higher HDL levels (P = 0.0039). This is the first time that haplotypes involving these polymorphisms were evaluated. Our results showed that these polymorphisms were involved in the development of obesity and in alterations of lipids and proteins serum levels in a Brazilian population. the present findings might also clarify the role of these polymorphisms and their haplotypes in lipids and proteins metabolism.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Div Genet, Dept Morphol & Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Div Genet, Dept Morphol & Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Med, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent511-517
dc.identifierhttp://dx.doi.org/10.1007/s11745-010-3426-z
dc.identifier.citationLipids. Heidelberg: Springer Heidelberg, v. 45, n. 6, p. 511-517, 2010.
dc.identifier.doi10.1007/s11745-010-3426-z
dc.identifier.issn0024-4201
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32584
dc.identifier.wosWOS:000279694900005
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofLipids
dc.rightsAcesso restrito
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectObesityen
dc.subjectGlycated hemoglobinen
dc.subjectPolymorphismsen
dc.subjectAPOA1en
dc.subjectAPOA5en
dc.subjectHDLen
dc.subjectHaplotypeen
dc.titleAPOA1/A5 Variants and Haplotypes as a Risk Factor for Obesity and Better Lipid Profiles in a Brazilian Elderly Cohorten
dc.typeArtigo
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