Effect of 6-month nutritional intervention on non-alcoholic fatty liver disease

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dc.contributor.authorElias, Maria Cristina [UNIFESP]
dc.contributor.authorParise, Edison Roberto [UNIFESP]
dc.contributor.authorCarvalho, Luciana de [UNIFESP]
dc.contributor.authorSzejnfeld, Denis [UNIFESP]
dc.contributor.authorNetto, Joao Prola [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:39Z
dc.date.available2016-01-24T14:05:39Z
dc.date.issued2010-11-01
dc.description.abstractObjective: We evaluated the effect of diet therapy as exclusive treatment on insulin resistance, biochemical parameters of metabolic syndrome, and degree of hepatic steatosis in patients with non-alcoholic fatty liver disease.Methods: Thirty-one patients with non-alcoholic fatty liver disease received a diet with a reduction of 500 to 1000 cal/d, containing 15% protein, 55% carbohydrates, and 30% fat, for 6 mo. At entry and 6 mo after dietary instructions, degrees of hepatic steatosis and visceral obesity were assessed by computed tomography: serum aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, glucose, triacylglycerols, and high-density lipoprotein cholesterol were measured by automated methods. Body mass index, waist circumference, waist-to-hip ratio, and food intake (7-d diary) were also evaluated. At the end of follow-up, the patients were classified as adherent or non-adherent to treatment according to a weight loss of more or less than 5% of initial body weight, respectively.Results: Seventeen patients were classified as adherent (group 1) and 14 as non-adherent (group 2). Group 2 only presented a significant reduction in body mass index and waist circumference. in contrast, in group 1, in addition to significant improvement of all anthropometric parameters, a significant reduction was observed in alanine aminotransferase and gamma-glutamyl transferase levels, homeostasis model assessment for insulin resistance, visceral fat and tomographic liver density, together with an increase in serum high-density lipoprotein cholesterol levels. These patients presented a significant decrease in total energy intake and in total and saturated fats.Conclusion: Nutritional intervention as exclusive treatment, with a loss of at least 5% of initial weight, is effective in the treatment of non-alcoholic fatty liver disease. (C) 2010 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Gastroenterol & Hepatol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Diagnost Image, Abdominal Div, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Gastroenterol & Hepatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Diagnost Image, Abdominal Div, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1094-1099
dc.identifierhttp://dx.doi.org/10.1016/j.nut.2009.09.001
dc.identifier.citationNutrition. New York: Elsevier B.V., v. 26, n. 11-12, p. 1094-1099, 2010.
dc.identifier.doi10.1016/j.nut.2009.09.001
dc.identifier.issn0899-9007
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33047
dc.identifier.wosWOS:000283569200012
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNutrition
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectInsulin resistanceen
dc.subjectNon-alcoholic fatty liver diseaseen
dc.subjectNon-alcoholic steatohepatitisen
dc.subjectObesityen
dc.subjectDieten
dc.subjectWaist circumferenceen
dc.titleEffect of 6-month nutritional intervention on non-alcoholic fatty liver diseaseen
dc.typeinfo:eu-repo/semantics/article
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