Asymmetrical changes in lumbar sympathetic nerve activity following stimulation of the sciatic nerve in rat

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dc.contributor.authorKorim, Willian Seiji
dc.contributor.authorMcMullan, Simon
dc.contributor.authorCravo, Sergio L. [UNIFESP]
dc.contributor.authorPilowsky, Paul M.
dc.contributor.institutionMacquarie Univ
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:16:46Z
dc.date.available2016-01-24T14:16:46Z
dc.date.issued2011-05-19
dc.description.abstractNoxious stimulation of the leg increases hind limb blood flow (HBF) to the ipsilateral side and decreases to the contralateral in rat. Whether or not this asymmetrical response is due to direct control by sympathetic terminals or mediated by other factors such as local metabolism and hormones remains unclear. the aim of this study was to compare responses in lumbar sympathetic nerve activity, evoked by stimulation of the ipsilateral and contralateral sciatic nerve (SN). We also sought to determine the supraspinal mechanisms involved in the observed responses. in anesthetized and paralyzed rats, intermittent electrical stimulation (1 mA, 0.5 Hz) of the contralateral SN evoked a biphasic sympathoexcitation. Following ipsilateral SN stimulation, the response is preceded by an inhibitory potential with a latency of 50 ms (N=26). Both excitatory and inhibitory potentials are abolished following cervical Cl spinal transection (N=6) or bilateral microinjections of muscimol (N=6) in the rostral ventrolateral medulla (RVLM). This evidence is suggestive that both sympathetic potentials are supraspinally mediated in this nucleus. Blockade of RVLM glutamate receptors by microinjection of kynurenic acid (N=4) selectively abolished the excitatory potential elicited by ipsilateral SN stimulation. This study supports the physiological model that activation of hind limb nociceptors evokes a generalized sympathoexcitation, with the exception of the ipsilateral side where there is a withdrawal of sympathetic tone resulting in an increase in HBF. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationMacquarie Univ, Australian Sch Adv Med, Sydney, NSW 2109, Australia
dc.description.affiliationUniv São Paulo, Programa Neurociencias & Comportamento, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipMacquarie Research Excellence scholarship
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipNational Health and Medical Research Council of Australia
dc.description.sponsorshipAustralian Research Council
dc.description.sponsorshipGarnett Passe and Rodney Williams Memorial Foundation
dc.description.sponsorshipMacquarie University
dc.description.sponsorshipIDNational Health and Medical Research Council of Australia: 457069
dc.description.sponsorshipIDNational Health and Medical Research Council of Australia: 457080
dc.description.sponsorshipIDNational Health and Medical Research Council of Australia: 604002
dc.description.sponsorshipIDAustralian Research Council: DP110102110
dc.format.extent60-70
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2011.03.057
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1391, p. 60-70, 2011.
dc.identifier.doi10.1016/j.brainres.2011.03.057
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33710
dc.identifier.wosWOS:000291290600007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSomatosympatheticen
dc.subjectRVLMen
dc.subjectPhrenic nerve dischargeen
dc.subjectBulbospinalen
dc.subjectPresympatheticen
dc.titleAsymmetrical changes in lumbar sympathetic nerve activity following stimulation of the sciatic nerve in raten
dc.typeinfo:eu-repo/semantics/article
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