Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder

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dc.contributor.authorMonkul, E. S.
dc.contributor.authorHatch, J. P.
dc.contributor.authorNicoletti, M. A.
dc.contributor.authorSpence, S.
dc.contributor.authorBrambilla, P.
dc.contributor.authorLacerda, Acioly Luiz Tavares de [UNIFESP]
dc.contributor.authorSassi, R. B.
dc.contributor.authorMallinger, A. G.
dc.contributor.authorKeshavan, M. S.
dc.contributor.authorSoares, J. C.
dc.contributor.institutionUniv Texas
dc.contributor.institutionAudie L Murphy Div
dc.contributor.institutionDokuz Eylul Univ
dc.contributor.institutionUniv Udine
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSci Inst IRCCS E Medea
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Pittsburgh
dc.contributor.institutionWayne State Univ
dc.date.accessioned2016-01-24T12:41:59Z
dc.date.available2016-01-24T12:41:59Z
dc.date.issued2007-04-01
dc.description.abstractOur knowledge about the neurobiology of suicide is limited. It has been proposed that suicidal behavior generally requires biological abnormalities concomitant with the personality trait of impulsivity/aggression, besides an acute psychiatric illness or psychosocial stressor. We investigated fronto-limbic anatomical brain abnormalities in suicidal and non-suicidal adult female patients with unipolar depression. Our sample consisted of seven suicidal unipolar patients, 10 non-suicidal unipolar patients and 17 healthy female comparison subjects. the criterion for suicidality was one or more documented lifetime suicide attempts. A 1.5T GE Signa Imaging System running version Signa 5.4.3 software was used to acquire the magnetic resonance imaging images. All anatomical structures were measured blindly, with the subjects' identities and group assignments masked. We used analysis of covariance with age and intracranial volume as covariates and the Tukey-Kramer procedure to compare suicidal patients, non-suicidal patients and healthy comparison subjects. Suicidal patients had smaller right and left orbitofrontal cortex gray matter volumes compared with healthy comparison subjects. Suicidal patients had larger right amygdala volumes than non-suicidal patients. Abnormalities in the orbitofrontal cortex and amygdala in suicidal patients may impair decision-making and predispose these patients to act more impulsively and to attempt suicide.en
dc.description.affiliationUniv Texas, Hlth Sci Ctr, Dept Psychiat, Div Mood & Anxiety Disorders,MOOD CNS Program, San Antonio, TX 78229 USA
dc.description.affiliationUniv Texas, Hlth Sci Ctr, Dept Orthodont, San Antonio, TX 78229 USA
dc.description.affiliationUniv Texas, Hlth Sci Ctr, Dept Radiol, San Antonio, TX 78229 USA
dc.description.affiliationAudie L Murphy Div, S Texas Vet Hlth Care Syst, San Antonio, TX USA
dc.description.affiliationDokuz Eylul Univ, Sch Med, Dept Psychiat, Izmir, Turkey
dc.description.affiliationUniv Udine, Dept Pathol & Expt & Clin Med, Sect Psychiat, I-33100 Udine, Italy
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, LiNC, São Paulo, Brazil
dc.description.affiliationSci Inst IRCCS E Medea, Udine, Italy
dc.description.affiliationUniv São Paulo, Inst Psychiat, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15260 USA
dc.description.affiliationWayne State Univ, Sch Med, Dept Psychiat & Behav Sci, Detroit, MI 48202 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, LiNC, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent360-366
dc.identifierhttp://dx.doi.org/10.1038/sj.mp.4001919
dc.identifier.citationMolecular Psychiatry. London: Nature Publishing Group, v. 12, n. 4, p. 360-366, 2007.
dc.identifier.doi10.1038/sj.mp.4001919
dc.identifier.issn1359-4184
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29600
dc.identifier.wosWOS:000245313200006
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofMolecular Psychiatry
dc.rightsAcesso aberto
dc.subjectsuicideen
dc.subjectdepressionen
dc.subjectmood disordersen
dc.subjectaffective disordersen
dc.subjectmagnetic resonance imagingen
dc.subjectlimbic systemen
dc.titleFronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorderen
dc.typeArtigo
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