Malnutrition in Infancy as a Susceptibility Factor for Temporal Lobe Epilepsy in Adulthood Induced by the Pilocarpine Experimental Model

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dc.contributor.authorCabral, Francisco Romero [UNIFESP]
dc.contributor.authorPriel, Margareth Rose
dc.contributor.authorSilva Araujo, Bruno Henrique [UNIFESP]
dc.contributor.authorTorres, Laila Brito [UNIFESP]
dc.contributor.authorLima, Eliangela de [UNIFESP]
dc.contributor.authorVale, Tiago Gurgel do [UNIFESP]
dc.contributor.authorPereira, Felipe [UNIFESP]
dc.contributor.authorAmorim, Henrique Alves de [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrao [UNIFESP]
dc.contributor.authorScerni, Debora Amado [UNIFESP]
dc.contributor.authorNaffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.institutionInst Israelita Ensino Pesquisa Albert Einstein
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCtr Univ Sao Camilo
dc.contributor.institutionCtr Nacl Primatas
dc.date.accessioned2016-01-24T14:06:02Z
dc.date.available2016-01-24T14:06:02Z
dc.date.issued2011-01-01
dc.description.abstractMalnutrition during the earliest stages of life may result in innumerable brain problems. Moreover, this condition could increase the chances of developing neurological diseases, such as epilepsy. We analyzed the effects of early-life malnutrition on susceptibility to epileptic seizures induced by the pilocarpine model of epilepsy. Wistar rat pups were kept on a starvation regimen from day 1 to day 21 after birth. At day 60, 16 animals (8 = well-nourished; 8 = malnourished) were exposed to the pilocarpine experimental model of epilepsy. Age-matched well-nourished (n = 8) and malnourished (n = 8) rats were used as controls. Animals were video-monitored over 9 weeks. the following behavioral parameters were evaluated: first seizure threshold (acute period of the pilocarpine model); status epilepticus (SE) latency; first spontaneous seizure latency (silent period), and spontaneous seizure frequency during the chronic phase. the cell and mossy fiber sprouting (MFS) density were evaluated in the hippocampal formation. Our results showed that the malnourished animals required a lower pilocarpine dose in order to develop SE (200 mg/kg), lower latency to reach SE, less time for the first spontaneous seizure and higher seizure frequency, when compared to well-nourished pilocarpine rats. Histopathological findings revealed a significant cell density reduction in the CA1 region and intense MFS among the malnourished animals. Our data indicate that early malnutrition greatly influences susceptibility to seizures and behavioral manifestations in adult life. These findings suggest that malnutrition in infancy reduces the threshold for epilepsy and promotes alterations in the brain that persist into adult life. Copyright (C) 2011 S. Karger AG, Baselen
dc.description.affiliationInst Israelita Ensino Pesquisa Albert Einstein, Inst Cerebro, BR-06780110 São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurocirurgia, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.affiliationCtr Univ Sao Camilo, São Paulo, Brazil
dc.description.affiliationCtr Nacl Primatas, Inst Evandro Chagas, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurocirurgia, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent469-478
dc.identifierhttp://dx.doi.org/10.1159/000330707
dc.identifier.citationDevelopmental Neuroscience. Basel: Karger, v. 33, n. 6, p. 469-478, 2011.
dc.identifier.doi10.1159/000330707
dc.identifier.issn0378-5866
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33337
dc.identifier.wosWOS:000301888600001
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofDevelopmental Neuroscience
dc.rightsAcesso restrito
dc.rights.licensehttp://www.karger.com/Services/RightsPermissions
dc.subjectEpilepsyen
dc.subjectMalnutritionen
dc.subjectBrain developmenten
dc.subjectHippocampusen
dc.subjectPilocarpineen
dc.titleMalnutrition in Infancy as a Susceptibility Factor for Temporal Lobe Epilepsy in Adulthood Induced by the Pilocarpine Experimental Modelen
dc.typeArtigo
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