Induced pluripotent stem cells reprogramming: Epigenetics and applications in the regenerative medicine

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dc.citation.issue2
dc.citation.volume63
dc.contributor.authorSampaio Gomes, Katia Maria
dc.contributor.authorCosta, Ismael Cabral
dc.contributor.authordos Santos, Jeniffer Farias [UNIFESP]
dc.contributor.authorMartins Dourado, Paulo Magno
dc.contributor.authorForni, Maria Fernanda
dc.contributor.authorBatista Ferreira, Julio Cesar
dc.coverageSao Paulo
dc.date.accessioned2020-07-17T14:03:02Z
dc.date.available2020-07-17T14:03:02Z
dc.date.issued2017
dc.description.abstractInduced pluripotent stem cells ( iPSCs) are somatic cells reprogrammed into an embryonic-like pluripotent state by the expression of specific transcription factors. iPSC technology is expected to revolutionize regenerative medicine in the near future. Despite the fact that these cells have the capacity to self-renew, they present low efficiency of reprogramming. Recent studies have demonstrated that the previous somatic epigenetic signature is a limiting factor in iPSC performance. Indeed, the process of effective reprogramming involves a complete remodeling of the existing somatic epigenetic memory, followed by the establishment of a "new epigenetic signature" that complies with the new type of cell to be differentiated. Therefore, further investigations of epigenetic modifications associated with iPSC reprogramming are required in an attempt to improve their self-renew capacity and potency, as well as their application in regenerative medicine, with a new strategy to reduce the damage in degenerative diseases. Our review aimed to summarize the most recent findings on epigenetics and iPSC, focusing on DNA methylation, histone modifications and microRNAs, highlighting their potential in translating cell therapy into clinics.en
dc.description.affiliationUniv Sao Paulo ICB III USP, Inst Biomed Sci III, Dept Anat, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Dept Biochem, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo InCor FMUSP, Fac Med, Inst Heart, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo IQ USP, Inst Chem, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Dept Biochem, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent180-189
dc.identifierhttp://dx.doi.org/10.1590/1806-9282.63.02.180
dc.identifier.citationRevista Da Associacao Medica Brasileira. Sao Paulo, v. 63, n. 2, p. 180-189, 2017.
dc.identifier.doi10.1590/1806-9282.63.02.180
dc.identifier.fileWOS000397875400014.pdf
dc.identifier.issn0104-4230
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55139
dc.identifier.wosWOS:000397875400014
dc.language.isoeng
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectinduced pluripotent stem cellsen
dc.subjectregenerative medicineen
dc.subjectcell reprogrammingen
dc.subjectepigeneticsen
dc.subjecthistonesen
dc.subjectmicroRNAsen
dc.titleInduced pluripotent stem cells reprogramming: Epigenetics and applications in the regenerative medicineen
dc.typeinfo:eu-repo/semantics/article
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