Cadmium-induced testicular injury

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dc.contributor.authorSiu, Erica Rosanna
dc.contributor.authorMruk, Dolores D.
dc.contributor.authorPorto, Catarina Segreti [UNIFESP]
dc.contributor.authorCheng, C. Yan
dc.contributor.institutionPopulat Council
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:58:36Z
dc.date.available2016-01-24T13:58:36Z
dc.date.issued2009-08-01
dc.description.abstractCadmium (Cd) is an environmental toxicant and an endocrine disrupter in humans and rodents. Several organs (e.g., kidney, liver) are affected by Cd and recent studies have illustrated that the testis is exceedingly sensitive to Cd toxicity. More important, Cd and other toxicants, such as heavy metals (e.g., lead, mercury) and estrogenic-based compounds (e.g., bisphenols) may account for the recent declining fertility in men among developed countries by reducing sperm count and testis function. in this review, we critically discuss recent data in the field that have demonstrated the Cd-induced toxicity to the testis is probably the result of interactions of a complex network of causes. This is likely to involve the disruption of the blood-testis barrier (BTB) via specific signal transduction pathways and signaling molecules, such as p38 mitogen-activated protein kinase (MAPK). We also summarize current studies on factors that confer and/or regulate the testis sensitivity to Cd, such as Cd transporters and metallothioneins, the impact of Cd on the testis as an endocrine disruptor and oxidative stress inducer, and how it may disrupt the Zn(2+) and/or Ca(2+) mediated cellular events. While much work is needed before a unified mechanistic pathway of Cd-induced testicular toxicity emerges, recent studies have helped to identify some of the likely mechanisms and/or events that take place during Cd-induced testis injury. Furthermore, some of the recent studies have shed lights on potential therapeutic or preventive approaches that can be developed in future studies by blocking or minimizing the destructive effects of Cd to testicular function in men. (C) 2009 Elsevier Inc. All rights reserveden
dc.description.affiliationPopulat Council, Ctr Biomed Res, Mary M Wohlford Lab Male Contracept Res, New York, NY 10065 USA
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pharmacol, Sect Expt Endocrinol,INFAR, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pharmacol, Sect Expt Endocrinol,INFAR, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pharmacol, Sect Expt Endocrinol,INFAR, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipIDNational Institutes of Health: R01 HD056034
dc.description.sponsorshipIDNational Institutes of Health: R03 HD051512
dc.description.sponsorshipIDNational Institutes of Health: U54 HD029990
dc.description.sponsorshipIDFAPESP: 06/51281-6pt
dc.format.extent240-249
dc.identifierhttps://dx.doi.org/10.1016/j.taap.2009.01.028
dc.identifier.citationToxicology and Applied Pharmacology. San Diego: Academic Press Inc Elsevier Science, v. 238, n. 3, p. 240-249, 2009.
dc.identifier.doi10.1016/j.taap.2009.01.028
dc.identifier.issn0041-008X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/31728
dc.identifier.wosWOS:000268147600007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicology and Applied Pharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectEnvironmental toxicanten
dc.subjectCadmiumen
dc.subjectTestisen
dc.subjectSpermatogenesisen
dc.subjectSeminiferous epithelial cycleen
dc.subjectSertoli cellsen
dc.subjectGerm cellsen
dc.subjectBlood-testis barrieren
dc.subjectCell adhesionen
dc.subjectInfertilityen
dc.subjectCanceren
dc.titleCadmium-induced testicular injuryen
dc.typeinfo:eu-repo/semantics/article
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