Biomarkers of oxidative stress and antioxidant status in children born small for gestational age: Evidence of lipid peroxidation

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dc.contributor.authorFranco, Maria do Carmo Pinho [UNIFESP]
dc.contributor.authorKawamoto, Elisa M.
dc.contributor.authorGorjao, Renata
dc.contributor.authorRastelli, Viviani M. F.
dc.contributor.authorCuri, Rui
dc.contributor.authorScavone, Cristoforo
dc.contributor.authorSawaya, Ana Lydia [UNIFESP]
dc.contributor.authorFortes, Zuleica Bruno
dc.contributor.authorSesso, Ricardo de Castro Cintra [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:48:54Z
dc.date.available2016-01-24T13:48:54Z
dc.date.issued2007-08-01
dc.description.abstractChildren born small for gestational age are known to be at increased risk for adult diseases such as hypertension, diabetes, and coronary heart disease. Oxidative stress is a common feature of these pathogenic conditions and can be the key link between size at birth and increased morbidity later in life. the purpose of this study was to analyze the parameters of lipoperoxidation and changes in antioxidant defense system as well as assess their relationship to birth weight. Concentrations of thiobarbituric-acid-reactive-substances and F-2-isoprostanes, total antioxidant status, and the activity of both superoxide dismutase and glutathione peroxidase were measured in 65 children (33 boys, 32 girls; ages 8-13 y). Thiobarbituric-acid-reactive-substances and F-2-isoprostane levels were significantly elevated in children born small for gestational age. Nevertheless, superoxide dismutase activity was significantly elevated in these children and the levels of both glutathione peroxidase activity and total antioxidant status were unchanged. Moreover, we found that systolic blood pressure was positively associated with thiobarbituric-acid-reactive-substances levels in race- and gender-adjusted models but not in a multivariable regression model. in conclusion, the current study revealed that there is evidence of oxidative stress in children born small for gestational age as supported by increased lipid peroxidation.en
dc.description.affiliationUniversidade Federal de São Paulo, Sch Med, Dept Physiol, Div Nephrol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Inst Biomed Sci, BR-00508070 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Med, Dept Physiol, Div Nephrol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent204-208
dc.identifierhttp://dx.doi.org/10.1203/PDR.0b013e3180986d04
dc.identifier.citationPediatric Research. Baltimore: Int Pediatric Research Foundation, Inc, v. 62, n. 2, p. 204-208, 2007.
dc.identifier.doi10.1203/PDR.0b013e3180986d04
dc.identifier.issn0031-3998
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29893
dc.identifier.wosWOS:000248339700019
dc.language.isoeng
dc.publisherInt Pediatric Research Foundation, Inc
dc.relation.ispartofPediatric Research
dc.rightsAcesso aberto
dc.titleBiomarkers of oxidative stress and antioxidant status in children born small for gestational age: Evidence of lipid peroxidationen
dc.typeArtigo
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