ADT-G as a promising biomarker for peripheral hyperandrogenism in adult female acne

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dc.citation.issue1
dc.citation.volume9
dc.contributor.authorRocha, Marco [UNIFESP]
dc.contributor.authorCardozo, Karina H. M.
dc.contributor.authorCarvalho, Valdemir M.
dc.contributor.authorBagatin, Edieia [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-08-04T13:39:51Z
dc.date.available2020-08-04T13:39:51Z
dc.date.issued2017
dc.description.abstractAcne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. Recent studies have shown an increasing number of cases of acne in adult women. These cases are predominantly normoandrogenic and present some clinical differences compared to adolescent acne. Local glandular metabolism turns some weak hormonal precursors into more active substances that increase the production of sebum, leaving these areas more prone to an increasing the colonization by Propionibacterium acnes (P. acnes). Our objective was to evaluate the usefulness of an androgenic metabolite as an adult female acne biomarker. The study population consisted of 38 adult women with acne without any features of hyperandrogenism and a control group. They were recruited from the clinic of Dermatology Hospital Division of Sao Paulo, Federal University of Sao Paulo from January 2012 to September 2014. After the first hormonal dosages, patients with acne were randomized into two different groups: one receiving a combined oral contraceptive (COC) containing 0,02 mg of ethinylestradiol and 3 mg drospirenone in a regimen of 24 days of medication, and the other group was treated with a topical gel containing 15% azelaic acid (AA), twice daily, both for six months. With the end of treatment new dosages were performed. Regarding the hormones, total and free testosterone and dehydroepiandrosterone sultate were quantified. In addition, the detection and quantification of androsterone glucuronate (ADT-G), an androgenic metabolite, has been developed. Only ADT-G was sensitive in detecting differences between the control and acne groups, and presented reduction of their values with systemic treatment. Therefore, only ADT-G was able to analyze the peripheral hyperandrogenism in cases of adult female acne.en
dc.description.affiliationUniv Fed Sao Paulo, EPM, Sao Paulo, Brazil
dc.description.affiliationGrp Fleury Pesquisa & Desenvolvimento, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, EPM, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.identifierhttp://dx.doi.org/10.1080/19381980.2017.1361571
dc.identifier.citationDermato-Endocrinology. Philadelphia, v. 9, n. 1, p. -, 2017.
dc.identifier.doi10.1080/19381980.2017.1361571
dc.identifier.fileWOS000428315900001.pdf
dc.identifier.issn1938-1972
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57149
dc.identifier.wosWOS:000428315900001
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofDermato-Endocrinology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcneen
dc.subjectadulten
dc.subjectfemaleen
dc.subjectbiomarkeren
dc.subjectADT-Gen
dc.subjectandrosterone glucuronideen
dc.titleADT-G as a promising biomarker for peripheral hyperandrogenism in adult female acneen
dc.typeinfo:eu-repo/semantics/article
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