Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine

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dc.citation.issue12
dc.citation.volume31
dc.contributor.authorEboli, Ligia Patricia de Carvalho Batista [UNIFESP]
dc.contributor.authorSalzedas-Netto, Alcides Augusto [UNIFESP]
dc.contributor.authorAzevedo, Ramiro Antero de [UNIFESP]
dc.contributor.authorLanzoni, Valeria Pereira [UNIFESP]
dc.contributor.authorPaula, Tatiana Sugayama de [UNIFESP]
dc.contributor.authorGoldenberg, Alberto [UNIFESP]
dc.contributor.authorGonzalez, Adriano Miziara [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-07-31T12:47:05Z
dc.date.available2020-07-31T12:47:05Z
dc.date.issued2016
dc.description.abstractPURPOSE: To describe an animal model for acute liver failure by intraperitoneal d-galactosamine injections in rats and to define when is the best time to intervene through King's College and Clichy's criteria evaluation. METHODS: Sixty-one Wistar female rats were distributed into three groups: group 1 (11 rats received 1.4 g/kg of d-galactosamine intraperitoneally and were observed until they died)en
dc.description.abstractgroup 2 (44 rats received a dose of 1.4 g/kg of d-galactosamine and blood and histological samples were collected for analysis at 12, 24, 48, 72 and 120 hours after the injection)en
dc.description.abstractand the control group as well (6 rats). RESULTS: Twelve hours after applying d-galactosamine, AST/ALT, bilirubin, factor V, PT and INR were already altered. The peak was reached at 48 hours. INR > 6.5 was found 12 hours after the injection and factor V < 30% after 24 hours. All the laboratory variables presented statistical differences, except urea (p = 0.758). There were statistical differences among all the histological variables analyzed. CONCLUSION: King's College and Clichy's criteria were fulfilled 12 hours after the d-galactosamine injection and this time may represent the best time to intervene in this acute liver failure animal model.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Postgrad Program Interdisciplinary Surg Sci, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Surg, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Sch Med, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Surg, Lab Surg Tech & Expt Surg, Sao Paulo, Brazil
dc.description.affiliationUnifespPostgraduate Program in Interdisciplinary Surgical Science, Universidade Federal de São Paulo (UNIFESP), Brazil
dc.description.affiliationUnifespDepartment of Surgery, Universidade Federal de São Paulo (UNIFESP), Sao Paulo-SP, Brazil
dc.description.affiliationUnifespPediatric Department, Universidade Federal de São Paulo (UNIFESP), Sao Paulo-SP, Brazil
dc.description.affiliationUnifespDepartment of Pathology, Universidade Federal de São Paulo (UNIFESP), Sao Paulo-SP, Brazil
dc.description.affiliationUnifespSchool of Medicine, Universidade Federal de São Paulo (UNIFESP), Sao Paulo-SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent783-792
dc.identifierhttp://dx.doi.org/10.1590/S0102-865020160120000002
dc.identifier.citationActa Cirurgica Brasileira. Sao Paulo, v. 31, n. 12, p. 783-792, 2016.
dc.identifier.doi10.1590/S0102-865020160120000002
dc.identifier.fileS0102-86502016001200783.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502016001200783
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56577
dc.identifier.wosWOS:000393790500002
dc.language.isoeng
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLiver Failure, Acuteen
dc.subjectGalactosamineen
dc.subjectModels, Animalen
dc.subjectRatsen
dc.titleEvaluating the best time to intervene acute liver failure in rat models induced by d-galactosamineen
dc.typeinfo:eu-repo/semantics/article
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