Gender Differences in Outcomes after Ischemic Stroke: Role of Ischemic Lesion Volume and Intracranial Large-Artery Occlusion

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dc.contributor.authorSilva, Gisele Sampaio [UNIFESP]
dc.contributor.authorLima, Fabricio O.
dc.contributor.authorCamargo, Erica C. S.
dc.contributor.authorSmith, Wade S.
dc.contributor.authorLev, Michael H.
dc.contributor.authorHarris, Gordon J.
dc.contributor.authorHalpern, Elkan F.
dc.contributor.authorKoroshetz, Walter
dc.contributor.authorFurie, Karen L.
dc.contributor.institutionMassachusetts Gen Hosp
dc.contributor.institutionHarvard Univ
dc.contributor.institutionUniv Calif San Francisco
dc.contributor.institutionNatl Inst Neurol Disorders & Stroke
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:01Z
dc.date.available2016-01-24T13:59:01Z
dc.date.issued2010-01-01
dc.description.abstractBackground: the reasons for gender disparities in stroke outcome remain unclear, and little is known about the value of acute neuroimaging characteristics in elucidating differential stroke outcomes between the sexes. Methods: We prospectively evaluated consecutive patients with acute ischemic stroke. CT angiography (CTA) was performed in all patients within 24 h of symptom onset. CTA source images were used to evaluate lesion volume. the primary outcome measure was a modified Rankin scale (mRS) score >= 3 at 6 months. Results: We evaluated 676 consecutive patients (322 women). Women were older than men (p < 0.01), more frequently had a prestroke mRS >0 (p < 0.01), and had higher admission National Institutes of Health Stroke scale scores (p = 0.01). More women had intracranial artery occlusions than men (46 vs. 33.1%, p = 0.01), but there was no significant difference between ischemic lesion volumes (p = 0.21). Using multiple regression, female gender remained an independent predictor of poor mRS scores at 6 months (odds ratio 1.57; 95% confidence interval 1.02-2.36) after adjustment for clinical and imaging covariates. Conclusion: Compared with men, women are less likely to achieve independence after acute ischemic stroke. the disparity in stroke outcome is not explained by differences in ischemic lesion volume or the presence of intracranial artery occlusions. Copyright (C) 2010 S. Karger AG, Baselen
dc.description.affiliationMassachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
dc.description.affiliationMassachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA
dc.description.affiliationHarvard Univ, Sch Med, Boston, MA USA
dc.description.affiliationUniv Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
dc.description.affiliationNatl Inst Neurol Disorders & Stroke, Bethesda, MD USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAgency for Healthcare Research and Quality
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipDeane Institute for Integrative Research in Stroke and Atrial Fibrillation
dc.description.sponsorshipLakeside Foundation
dc.description.sponsorshipIDAgency for Healthcare Research and Quality: AHRQ R01 HS11392
dc.description.sponsorshipIDNational Institutes of Health: P50NS051343
dc.format.extent470-475
dc.identifierhttp://dx.doi.org/10.1159/000317088
dc.identifier.citationCerebrovascular Diseases. Basel: Karger, v. 30, n. 5, p. 470-475, 2010.
dc.identifier.doi10.1159/000317088
dc.identifier.issn1015-9770
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32038
dc.identifier.wosWOS:000282752200006
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofCerebrovascular Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.karger.com/Services/RightsPermissions
dc.subjectSex differencesen
dc.subjectIschemic strokeen
dc.subjectCT angiographyen
dc.titleGender Differences in Outcomes after Ischemic Stroke: Role of Ischemic Lesion Volume and Intracranial Large-Artery Occlusionen
dc.typeinfo:eu-repo/semantics/article
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