Angiomirs expression profiling in diffuse large B-Cell lymphoma

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dc.citation.issue4
dc.citation.volume7
dc.contributor.authorBorges, Natalia M. [UNIFESP]
dc.contributor.authorElias, Marcela do Vale [UNIFESP]
dc.contributor.authorFook-Alves, Veruska L. [UNIFESP]
dc.contributor.authorAndrade, Tathiana A. [UNIFESP]
dc.contributor.authorde Conti, Marina Lourenco [UNIFESP]
dc.contributor.authorMacedo, Mariana Petaccia
dc.contributor.authorBegnami, Maria Dirlei
dc.contributor.authorCampos, Antonio Hugo J. F. M.
dc.contributor.authorEtto, Leina Yukari [UNIFESP]
dc.contributor.authorBortoluzzo, Adriana Bruscato
dc.contributor.authorAlves, Antonio C. [UNIFESP]
dc.contributor.authorYoung, Ken H.
dc.contributor.authorColleoni, Gisele W. B. [UNIFESP]
dc.coverageOrchard Park
dc.date.accessioned2020-11-03T14:40:40Z
dc.date.available2020-11-03T14:40:40Z
dc.date.issued2016
dc.description.abstractDespite advances in treatment, 30% of diffuse large B-cell lymphoma (DLBCL) cases are refractory or relapse after chemoimmunotherapy. Currently, the relationship between angiogenesis and angiomiRs in DLBCL is unknown. We classified 84 DLBCL cases according to stromal signatures and evaluated the expression of pro-and antiangiomiRs in paraffin embedded tissues of DLBCL and correlated them with microvascular density (MVD). 40% of cases were classified as stromal-1, 50% as stromal-2 and 10% were not classified. We observed increased expression of proangiomiRs Let-7f, miR-17, miR-18a, miR-19b, miR-126, miR-130a, miR-210, miR-296 and miR-378 in 14%, 57%, 30%, 45%, 12%, 12%, 56%, 58% and 48% of the cases, respectively. Among antiangiomiRs we found decreased expression of miR-16, miR-20b, miR-92a, miR-221 and miR-328 in, respectively, 27%, 71%, 2%, 44% and 11%. We found association between increased expression of proangiomiRs miR-126 and miR-130a and antiangiomiR miR-328 and the subtype non-GCB. We found higher levels of the antiangiomiRs miR-16, miR-221 and miR-328 in patients with low MVD and stromal-1 signature. IPI and CD34 confirmed independent impact on survival of the study group. None of the above angiomiRs showed significance as biomarker in an independent serum samples cohort of patients and controls. In conclusion, we confirmed association between antiangiomiRs miR-16, miR-221 and miR-328 and stromal-1 signature. Four angiomiRs emerged as potential therapeutic targets: proangiomiRs miR-17, miR-210 and miR-296 and antiangiomiR miR-20b. Although the four microRNAs seem to be important in DLBCL pathogenesis, they were not predictive of DLBCL onset or relapse in the serum independent cohort.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, Brazil
dc.description.affiliationAC Camargo Canc Ctr, Sao Paulo, Brazil
dc.description.affiliationInsper Inst Educ & Res, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Patol, Sao Paulo, Brazil
dc.description.affiliationUniv Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Patol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil
dc.description.sponsorshipIDFAPESP: 2010/17668-6
dc.format.extent4806-4816
dc.identifierhttps://doi.org/10.18632/oncotarget.6624
dc.identifier.citationOncotarget. Orchard Park, v. 7, n. 4, p. 4806-4816, 2016.
dc.identifier.doi10.18632/oncotarget.6624
dc.identifier.fileWOS000369952400086.pdf
dc.identifier.issn1949-2553
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58673
dc.identifier.wosWOS:000369952400086
dc.language.isoeng
dc.publisherImpact Journals Llc
dc.relation.ispartofOncotarget
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectlymphomaen
dc.subjectangiogenesisen
dc.subjectmicroRNAsen
dc.titleAngiomirs expression profiling in diffuse large B-Cell lymphomaen
dc.typeinfo:eu-repo/semantics/article
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