Mycophenolate Mofetil Initiation in Renal Transplant Patients at Different Times Posttransplantation: the TranCept Switch Study

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dc.contributor.authorMeier-Kriesche, Herwig-Ulf
dc.contributor.authorMerville, Pierre
dc.contributor.authorTedesco-Silva, Helio [UNIFESP]
dc.contributor.authorHeemann, Uwe
dc.contributor.authorKes, Petar
dc.contributor.authorHaller, Hermann
dc.contributor.authorRostaing, Lionel
dc.contributor.authorGafner, Nesrin
dc.contributor.authorBernasconi, Corrado
dc.contributor.institutionUniv Florida
dc.contributor.institutionHop Pellegrin
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionTech Univ Munich
dc.contributor.institutionUniv Hosp Ctr Zagreb
dc.contributor.institutionHannover Med Sch
dc.contributor.institutionCHU Rangueil
dc.contributor.institutionNesrin Gafner Consulting
dc.contributor.institutionF Hoffmann La Roche & Co Ltd
dc.date.accessioned2016-01-24T14:16:46Z
dc.date.available2016-01-24T14:16:46Z
dc.date.issued2011-05-15
dc.description.abstractBackground. Despite evidence of favorable long-term effects of mycophenolate mofetil (MMF) in renal transplantation, its introduction at different times posttransplant has not been studied in large cohorts.Methods. Single-organ renal allograft recipients (n=2217) who had MMF introduced 6 months to more than 20 years posttransplantation for various reasons were included in TranCept Switch, a multicenter, noninterventional, observational 4-year study. Changes in renal function before and after the introduction of MMF were analyzed.Results. MMF was introduced because of renal function decline in 43% of patients and poor tolerability with previous treatment in 23% of patients. the change in slope of the calculated glomerular filtration rate (modification of diet in renal diseases formula) regression line before and after MMF initiation was +2.01 mL/min per year (P<0.001) on average. the greatest benefit was noted in patients who received MMF because of renal function decline and in whom calcineurin inhibitor treatment was subsequently reduced or withdrawn (+3.09 mL/min per year). Time from transplantation to MMF introduction influenced the glomerular filtration rate at MMF initiation (slow progressive deterioration) but not the direction of the slope change, which was positive even for late introduction.Conclusion. MMF introduction may be associated with improvement or stabilization of renal function even several years after transplantation.en
dc.description.affiliationUniv Florida, Coll Med, Div Nephrol, Gainesville, FL 32610 USA
dc.description.affiliationHop Pellegrin, Serv Nephrol Transplantat Dialyse, F-33076 Bordeaux, France
dc.description.affiliationUniversidade Federal de São Paulo, Hosp Rim & Hipertensao, São Paulo, Brazil
dc.description.affiliationTech Univ Munich, Klinikum Rechts Isar, Chirurg Klin, D-8000 Munich, Germany
dc.description.affiliationUniv Hosp Ctr Zagreb, Dept Internal Med, Zagreb, Croatia
dc.description.affiliationHannover Med Sch, Nephrol Abt, D-30623 Hannover, Germany
dc.description.affiliationCHU Rangueil, Dept Nephrol Dialysis & Organ Transplantat, F-31054 Toulouse, France
dc.description.affiliationNesrin Gafner Consulting, Biel, Switzerland
dc.description.affiliationF Hoffmann La Roche & Co Ltd, CH-4002 Basel, Switzerland
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Hosp Rim & Hipertensao, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipF. Hoffmann-La Roche Ltd.
dc.description.sponsorshipBasel, Switzerland
dc.description.sponsorshipBristol Meyer Squibb
dc.description.sponsorshipGilead
dc.description.sponsorshipLife cycle Pharma
dc.description.sponsorshipNovartis
dc.description.sponsorshipPfizer
dc.description.sponsorshipAstellas
dc.description.sponsorshipForest
dc.description.sponsorshipJansen-Cilag
dc.format.extent984-990
dc.identifierhttp://dx.doi.org/10.1097/TP.0b013e3182130966
dc.identifier.citationTransplantation. Philadelphia: Lippincott Williams & Wilkins, v. 91, n. 9, p. 984-990, 2011.
dc.identifier.doi10.1097/TP.0b013e3182130966
dc.identifier.issn0041-1337
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33707
dc.identifier.wosWOS:000289773000011
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofTransplantation
dc.rightsAcesso restrito
dc.subjectMycophenolate mofetilen
dc.subjectCalcineurin inhibitor withdrawalen
dc.subjectGlomerular filtration rateen
dc.subjectNephrotoxicityen
dc.titleMycophenolate Mofetil Initiation in Renal Transplant Patients at Different Times Posttransplantation: the TranCept Switch Studyen
dc.typeArtigo
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