Lymphocyte proliferation stimulated by activated Cebus apella macrophages treated with a complex homeopathic immune response modifiers

Página do item simplificado
dc.contributor.authorCoelho Moreira, Carlos Onete
dc.contributor.authorFerreira Borges da Costa, Joana de Fatima
dc.contributor.authorLeal, Mariana Ferreira [UNIFESP]
dc.contributor.authorAndrade, Edilson Ferreira de
dc.contributor.authorRezende, Alexandre Pingarilho
dc.contributor.authorImbeloni, Aline Amaral
dc.contributor.authorPereira Carneiro Muniz, Jose Augusto
dc.contributor.authorCardoso Smith, Marilia de Arruda [UNIFESP]
dc.contributor.authorBurbano, Rommel Rodriguez
dc.contributor.authorAssumpcao, Paulo Pimentel de
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFed Univ Para
dc.contributor.institutionMinist Saude
dc.date.accessioned2016-01-24T14:17:42Z
dc.date.available2016-01-24T14:17:42Z
dc.date.issued2012-01-01
dc.description.abstractIntroduction: Canova is a complex homeopathic medicine that enhances a specific immunologic responses against several exogenous and endogenous conditions. Canova activates macrophages both in vivo and in vitro.Aim and method: We evaluated the effects of macrophages activated by Canova in vivo and ex vitro in the proliferation of lymphocytes. Canova was used to activate Cebus apella macrophages in vivo or ex vitro with Canova. Lymphocytes were cultured with the macrophage culture medium. the analysis of Canova effects in cultured lymphocytes was performed according to the cell cycle phase using flow cytometry. the Interferon gamma and Interleukin-5 cytokines quantification in these lymphocyte culture media was performed by Enzyme-linked immunosorbent assay (ELISA).Results: We observed that Canova actives macrophages in vivo and ex vitro. the lymphocytes cultured in a supplemented medium with macrophages activated by Canova treatment presented a higher number of proliferation cells than lymphocytes not exposed to macrophages activated by Canova. the Interferon gamma and Interleukin-5 cytokines were only observed in the medium of lymphocytes exposed to macrophages activated by Canova. Thus, Canova has potential as a new adjuvant therapy. Homeopathy (201 2) 101, 74-79.en
dc.description.affiliationUniversidade Federal de São Paulo, Discipline Genetica, Dept Morfol & Genetica, BR-04023900 São Paulo, Brazil
dc.description.affiliationFed Univ Para, Lab Citogenetica Humana, Inst Ciencias Biol, BR-66059 Belem, PA, Brazil
dc.description.affiliationFed Univ Para, Serv Cirurgia, Hosp Univ Joao de Barros Barreto, BR-66073000 Belem, PA, Brazil
dc.description.affiliationMinist Saude, Ctr Nacl Primatas, BR-77030000 Ananindeua, PA, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Discipline Genetica, Dept Morfol & Genetica, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDCNPq: 550885/2007-2
dc.description.sponsorshipIDCNPq: 302774/2009-2
dc.description.sponsorshipIDCNPq: 301609/2007-1
dc.description.sponsorshipIDFAPESP: 2007/02470-3
dc.format.extent74-79
dc.identifierhttp://dx.doi.org/10.1016/j.homp.2011.09.001
dc.identifier.citationHomeopathy. Oxford: Elsevier B.V., v. 101, n. 1, p. 74-79, 2012.
dc.identifier.doi10.1016/j.homp.2011.09.001
dc.identifier.issn1475-4916
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34451
dc.identifier.wosWOS:000299607000012
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofHomeopathy
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCanovaen
dc.subjectImmune response modificationen
dc.subjectCell cycleen
dc.subjectCytokinesen
dc.subjectNon-human primatesen
dc.subjectCebus apellaen
dc.titleLymphocyte proliferation stimulated by activated Cebus apella macrophages treated with a complex homeopathic immune response modifiersen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos