Evidences of herbal medicine-derived natural products effects in inflammatory lung diseases

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dc.contributor.authorSantana, Fernanda Paula Roncon [UNIFESP]
dc.contributor.authorPinheiro, Nathalia Montouro
dc.contributor.authorMernak, Marcia Isabel Bittencourt [UNIFESP]
dc.contributor.authorRighetti, Renato Fraga
dc.contributor.authorMartins, Milton de Arruda
dc.contributor.authorLago, Joao Henrique Ghilardi [UNIFESP]
dc.contributor.authorLopes, Fernanda Degobbi Tenorio Quirino dos Santos
dc.contributor.authorTiberio, Iolanda de Fátima Lopes Calvo
dc.contributor.authorPrado, Carla Máximo [UNIFESP]
dc.date.accessioned2019-01-21T10:29:54Z
dc.date.available2019-01-21T10:29:54Z
dc.date.issued2016
dc.description.abstractPulmonary inflammation is a hallmark of many respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and acute respiratory syndrome distress (ARDS). Most of these diseases are treated with anti-inflammatory therapy in order to prevent or to reduce the pulmonary inflammation. Herbal medicine-derived natural products have been used in folk medicine and scientific studies to evaluate the value of these compounds have grown in recent years. Many substances derived from plants have the biological effects in vitro and in vivo, such as flavonoids, alkaloids, and terpenoids. Among the biological activities of natural products derived from plants can be pointed out the anti-inflammatory, antiviral, antiplatelet, antitumor anti-allergic activities, and antioxidant. Although many reports have evaluated the effects of these compounds in experimental models, studies evaluating clinical trials are scarce in the literature. This review aims to emphasize the effects of these different natural products in pulmonary diseases in experimental models and in humans and pointing out some possible mechanisms of action.en
dc.description.affiliationInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Federal University of São Paulo, Diadema-SP 09972-270, Brazil
dc.description.affiliationSchool of Medicine, University of São Paulo, São Paulo-SP 01246903, Brazil
dc.description.affiliationInstituto de Saúde e Sociedade, Federal University of São Paulo, Santos-SP 11015-020, Brazil
dc.description.affiliationUnifespInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Federal University of São Paulo, Diadema-SP 09972-270, Brazil
dc.description.affiliationUnifespInstituto de Saúde e Sociedade, Federal University of São Paulo, Santos-SP 11015-020, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipIDCNPq: 300546/2012-2
dc.description.sponsorshipIDCNPq: 304465/2012-7
dc.description.sponsorshipIDCNPq: 476877/2012-1
dc.description.sponsorshipIDFAPESP: 2010/14831-3
dc.description.sponsorshipIDFAPESP: 2011/15817-7
dc.description.sponsorshipIDFAPESP: 2008/55359-5
dc.identifierhttps://dx.doi.org/10.1155/2016/2348968
dc.identifier.citationMediators Of Inflammation. London, 2016.
dc.identifier.doi10.1155/2016/2348968
dc.identifier.fileWOS000379440900001.pdf
dc.identifier.issn0962-9351
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/49462
dc.identifier.wosWOS:000379440900001
dc.language.isoeng
dc.publisherIop Publishing Ltd
dc.relation.ispartofMediators Of Inflammation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectObstructive Pulmonary-Diseaseen
dc.subjectRespiratory-Distress-Syndromeen
dc.subjectAllergic Airway Inflammationen
dc.subjectSmoke-Induced Emphysemaen
dc.subjectIntestinal Ischemia-Reperfusionen
dc.subjectElastase-Induced Emphysemaen
dc.subjectRho-Kinase Inhibitionen
dc.subjectAsthma Murine Modelen
dc.subjectAntiinflammatory Activityen
dc.subjectGuinea-Pigsen
dc.titleEvidences of herbal medicine-derived natural products effects in inflammatory lung diseasesen
dc.typeinfo:eu-repo/semantics/review
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