Bcl-2 oncogene expression in estrogen receptor-positive and negative breast carcinoma

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dc.contributor.authorSantos, L. G. dos
dc.contributor.authorLopes-Costa, P. V.
dc.contributor.authorSantos, A. R. dos
dc.contributor.authorFacina, Gil [UNIFESP]
dc.contributor.authorSilva, B. B. da
dc.contributor.institutionUniv Fed Piaui
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:22:25Z
dc.date.available2018-06-15T17:22:25Z
dc.date.issued2008-01-01
dc.description.abstractPurpose: The aim of this study was to evaluate Bcl-2 oncogene expression in estrogen receptor (ER)-positive and negative breast carcinomas. Methods: A Study involving 72 cases of infiltrating ductal carcinoma of the breast in postmenopausal women divided into two groups: Group A (ER positive, n = 37) and Group B (ER negative, n = 35). Immunohistochemical analysis of bcl-2 expression was carried out semiquantitatively based on the percentage of stained tumoral cells and the intensity of staining. The chi-square test was used in the statistical analysis of the data and significance was established at p < 0.05. Results: Bcl-2 oncogene expression was statistically greater in tumors of Group A (59.5%) compared to those of Group B (8.6%), (p < 0.001). Conclusion: Bcl-2 had a significantly greater expression in the ER-positive breast tumors compared to ER-negative tumors.en
dc.description.affiliationUniv Fed Piaui, Dept Pathol, Teresina, Piaui, Brazil
dc.description.affiliationUniv Fed Piaui, Dept Gynecol, Teresina, Piaui, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Gynecol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Gynecol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent459-461
dc.identifierhttp://www.irog.net/download/?magazine=91
dc.identifier.citationEuropean Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 29, n. 5, p. 459-461, 2008.
dc.identifier.issn0392-2936
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43598
dc.identifier.wosWOS:000259328800008
dc.language.isoeng
dc.publisherI R O G Canada, Inc
dc.relation.ispartofEuropean Journal Of Gynaecological Oncology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbreasten
dc.subjectcanceren
dc.subjectapoptosisen
dc.subjectestrogen receptoren
dc.subjectbcl-2en
dc.titleBcl-2 oncogene expression in estrogen receptor-positive and negative breast carcinomaen
dc.typeinfo:eu-repo/semantics/article
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