Type of fatty acids in maternal diets during pregnancy and/or lactation and metabolic consequences of the offspring

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dc.contributor.authorMennitti, Lais Vales [UNIFESP]
dc.contributor.authorOliveira, Juliana Lopez de [UNIFESP]
dc.contributor.authorMorais, Carina Almeida [UNIFESP]
dc.contributor.authorEstadella, Debora [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorPisani, Luciana Pellegrini [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:39:55Z
dc.date.available2016-01-24T14:39:55Z
dc.date.issued2015-02-01
dc.description.abstractDuring pregnancy and/or lactation, maternal nutrition is related to the adequate development of the fetus, newborn and future adult, likely by modifications in fetal programming and epigenetic regulation. Fetal programming is characterized by adaptive responses to specific environmental conditions during early life stages, which may alter gene expression and permanently affect the structure and function of several organs and tissues, thus influencing the susceptibility to metabolic disorders. Regarding lipid metabolism during the first two trimesters of pregnancy, the maternal body accumulates fat, whereas in late pregnancy, the lipolytic activity in the maternal adipose tissue is increased. However, an excess or deficiency of certain fatty acids may lead to adverse consequences to the fetuses and newborns. Fetal exposure to trans fatty acids appears to promote early deleterious effects in the offspring's health, thereby increasing the individual risk for developing metabolic diseases throughout life. Similarly, the maternal intake of saturated fatty acids seems to trigger alterations in the liver and adipose tissue function associated with insulin resistance and diabetes. the polyunsaturated fatty acids (PUFAs), particularly long-chain PUFAs (long-chain PUFA-arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid), play an important and beneficial physiologic role in the offspring who receive this fatty acid during critical periods of development. Therefore, the maternal nutritional condition and fatty acid intake during pregnancy and/or lactation are critical factors that are strongly associated with normal fetal and postnatal development, which influence the modifications in fetal programming and in the individual risk for developing metabolic diseases throughout life. (C) 2015 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biociencias, Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biociencias, Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.format.extent99-111
dc.identifierhttp://dx.doi.org/10.1016/j.jnutbio.2014.10.001
dc.identifier.citationJournal of Nutritional Biochemistry. New York: Elsevier B.V., v. 26, n. 2, p. 99-111, 2015.
dc.identifier.doi10.1016/j.jnutbio.2014.10.001
dc.identifier.issn0955-2863
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38647
dc.identifier.wosWOS:000349578300001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Nutritional Biochemistry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectFatty acidsen
dc.subjectProgrammingen
dc.subjectPregnancyen
dc.subjectLactationen
dc.subjectMetabolismen
dc.titleType of fatty acids in maternal diets during pregnancy and/or lactation and metabolic consequences of the offspringen
dc.typeinfo:eu-repo/semantics/article
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