Impact of sex on hyperalgesia induced by sleep loss

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dc.contributor.authorAraujo, Paula [UNIFESP]
dc.contributor.authorMazaro-Costa, Renata
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2016-01-24T14:05:50Z
dc.date.available2016-01-24T14:05:50Z
dc.date.issued2011-01-01
dc.description.abstractThis study evaluated the impact of sex on the short term consequences of different periods of sleep deprivation and the effect of the respective sleep recovery periods on nociceptive responses. Male and female C57BL/6J mice were assigned to the following groups: paradoxical sleep deprived (PSD) for 72 h, sleep restricted (SR) for 15 days, exposed to respective recovery periods for 24 h, or untreated home-cage controls (CTRL). Mice were submitted to a noxious thermal stimulus to evaluate their nociceptive response after PSD, SR, or recovery periods. Blood was collected for hormonal analysis. the nociceptive response was significantly lower in PSD and SR mice compared to CTRL animals, regardless of the sex. However, SR females had a lower paw withdrawal threshold than males. Sleep recovery was able to restore normal nociceptive sensitivity after PSD in both sexes. the hyperalgesia induced by SR was not reversed by sleep rebound. in females, low concentrations of estradiol were found after SR, and these concentrations continued to decrease after 24 hours of sleep recovery. the PSD male mice exhibited higher concentrations of corticosterone than the CTRL and SR male mice. Corticosterone levels were not affected by SR. Our study revealed that PSD and SR induce hyperalgesia in mice. the SR groups showed marked changes in the nociceptive response, and the females were more sensitive to these alterations. This finding indicates that, although different periods of sleep deprivation change the nociceptive sensitivity in male and female mice, sex could influence hyperalgesia induced by chronic sleep loss. (C) 2010 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv Fed Goias, Dept Ciencias Fisiol, Goiania, Go, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Psicofarmacologia (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 98/14303-3
dc.description.sponsorshipIDFAPESP: 10/50130-0
dc.format.extent174-179
dc.identifierhttp://dx.doi.org/10.1016/j.yhbeh.2010.11.003
dc.identifier.citationHormones and Behavior. San Diego: Academic Press Inc Elsevier Science, v. 59, n. 1, p. 174-179, 2011.
dc.identifier.doi10.1016/j.yhbeh.2010.11.003
dc.identifier.fileWOS000286717600023.pdf
dc.identifier.issn0018-506X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33183
dc.identifier.wosWOS:000286717600023
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofHormones and Behavior
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSleep deprivationen
dc.subjectHyperalgesiaen
dc.subjectSex differencesen
dc.subjectCorticosteroneen
dc.subjectEstradiolen
dc.subjectHormonesen
dc.subjectMiceen
dc.titleImpact of sex on hyperalgesia induced by sleep lossen
dc.typeinfo:eu-repo/semantics/article
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