Antimicrobial resistance in Enterobacteriaceae in Brazil: focus on beta-lactams and polymyxins

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dc.citation.volume47
dc.contributor.authorMello Sampaio, Jorge Luiz
dc.contributor.authorGales, Ana Cristina [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-07-31T12:47:05Z
dc.date.available2020-07-31T12:47:05Z
dc.date.issued2016
dc.description.abstracturing the last 30 years there has been a dissemination of plasmid-mediated beta-lactamases in Enterobacteriaceae in Brazil. Extended spectrum beta-lactamases (ESBL) are widely disseminated in the hospital setting and are detected in a lower frequency in the community setting. Cefotaximases are the most frequently detected ESBL type and Klebsiella pneumoniae is the predominant species among ESBL producers. Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae became widely disseminated in Brazil during the last decade and KPC production is currently the most frequent resistance mechanism (96.2%) in carbapenem resistant K. pneumoniae. To date KPC-2 is the only variant reported in Brazil. Polymyxin B resistance in KPC-2-producing K. pneumoniae has come to an alarming rate of 27.1% in 2015 in Sao Paulo, the largest city in Brazil. New Delhi metallo-beta-lactamase was detected in Brazil in 2013, has been reported in different Brazilian states but are not widely disseminated. Antimicrobial resistance in Enterobacteriaceae in Brazil is a very serious problem that needs urgent actions which includes both more strict adherence to infection control measures and more judicious use of antimicrobials.(C) 2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda.en
dc.description.affiliationUniv Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo, SP, Brazil
dc.description.affiliationFleury Med & Saude, Secao Microbiol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Med Interna, Sao Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Medicina Interna, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent31-37
dc.identifierhttp://dx.doi.org/10.1016/j.bjm.2016.10.002
dc.identifier.citationBrazilian Journal Of Microbiology. Sao Paulo, v. 47, p. 31-37, 2016.
dc.identifier.doi10.1016/j.bjm.2016.10.002
dc.identifier.issn1517-8382
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56576
dc.identifier.wosWOS:000394047600003
dc.language.isoeng
dc.publisherSoc Brasileira Microbiologia
dc.relation.ispartofBrazilian Journal Of Microbiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectESBLen
dc.subjectKPCen
dc.subjectNDMen
dc.subjectExtended spectrum beta-lactamasesen
dc.subjectNew Delhi Metallo-beta-lactamasesen
dc.subjectKlebsiella pneumoniae carbapenemaseen
dc.subjectPolymyxin Ben
dc.subjectColistinen
dc.subjectAntimicrobial resistanceen
dc.subjectCarbapenemasesen
dc.subjectBrazil Enterobacteriaceaeen
dc.titleAntimicrobial resistance in Enterobacteriaceae in Brazil: focus on beta-lactams and polymyxinsen
dc.typeinfo:eu-repo/semantics/article
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