Histological evidence of reparative activity in chorioamniotic membrane following open fetal surgery for myelomeningocele

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dc.citation.issue4
dc.citation.volume14
dc.contributor.authorCarvalho, Natalia S. [UNIFESP]
dc.contributor.authorMoron, Antonio F. [UNIFESP]
dc.contributor.authorMenon, Ramkumar
dc.contributor.authorCavalheiro, Sergio [UNIFESP]
dc.contributor.authorBarbosa, Mauricio M. [UNIFESP]
dc.contributor.authorMilani, Herbene J. [UNIFESP]
dc.contributor.authorIshigai, Marcia M. [UNIFESP]
dc.coverageAthens
dc.date.accessioned2020-08-04T13:40:08Z
dc.date.available2020-08-04T13:40:08Z
dc.date.issued2017
dc.description.abstractAn increased understanding of the reparative process in fetal membrane following surgical techniques may be helpful to decrease the risks to mother and fetus and avoid adverse pregnancy outcomes. The present study discusses histological evaluation of the fetal membrane following open fetal surgery. Chorioamniotic membranes (n=10) were obtained following birth from pregnancies that underwent open fetal surgery for myelomeningocele. The collagen distribution was quantified using picrosirius-polarization method comparing the suture site with non-suture site. The differences between the collagen fiber percentages at the two sites was evaluated by the paired t-test with P<0.05. The mean gestational age of fetal surgery was 26.09 +/- 0.3 and 33.81 +/- 0.82 weeks at birth. The picrosirius red sign was more intense at the suture site, primarily associated with collagen type 1. Collagen observed in the surgical area was significantly increased (13.22 +/- 2.84%) compared with the non-surgical area (6.16 +/- 1.09%en
dc.description.abstractP<0.0001). It was observed that the reparative activity at the suture site of the fetal membrane was characterized by a significant increase in collagen fibers. The findings suggest nascent collagen synthesis, tissue remodeling and repair of suture site, a mechanism likely to prevent the amniotic fluid leakage and maintain pregnancy following open fetal surgery.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Obstet, Av Itapaiuna 1800,Apt 211, BR-04021001 Sao Paulo, SP, Brazil
dc.description.affiliationHosp & Maternidade Santa Joana, Fetal Med Div, BR-04103000 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Texas Med Branch, Dept Obstet & Gynecol, Galveston, TX 77555 USA
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Neurosurg, BR-04021001 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Pathol, BR-04021001 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Obstet, Av Itapaiuna 1800,Apt 211, BR-04021001 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Neurosurg, BR-04021001 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Pathol, BR-04021001 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES, Brazil
dc.format.extent3732-3736
dc.identifierhttp://dx.doi.org/10.3892/etm.2017.4976
dc.identifier.citationExperimental And Therapeutic Medicine. Athens, v. 14, n. 4, p. 3732-3736, 2017.
dc.identifier.doi10.3892/etm.2017.4976
dc.identifier.fileWOS000410732400143.pdf
dc.identifier.issn1792-0981
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57310
dc.identifier.wosWOS:000410732400143
dc.language.isoeng
dc.publisherSpandidos Publ Ltd
dc.relation.ispartofExperimental And Therapeutic Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectfetal membrane repairen
dc.subjectfetal membrane healingen
dc.subjectmyelomeningoceleen
dc.subjectopen fetal surgeryen
dc.subjectspina bifidaen
dc.titleHistological evidence of reparative activity in chorioamniotic membrane following open fetal surgery for myelomeningoceleen
dc.typeinfo:eu-repo/semantics/article
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