Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient

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dc.contributor.authorCamargo, Rosalinda Yossie Asato de
dc.contributor.authorKanamura, Cristina Takami
dc.contributor.authorFriguglietti, Celso Ubirajara
dc.contributor.authorNogueira, Celia Regina
dc.contributor.authorIorcansky, Sonia
dc.contributor.authorTincani, Alfio Jose
dc.contributor.authorBezerra, Ana Karina
dc.contributor.authorBrust, Ester
dc.contributor.authorKoyama, Fernanda Christtanini
dc.contributor.authorCamargo, Anamaria Aranha
dc.contributor.authorRego, Fernanda Orpinelli Ramos do
dc.contributor.authorGalante, Pedro Alexandre Favoretto
dc.contributor.authorMedeiros-Neto, Geraldo
dc.contributor.authorRubio, Ileana Gabriela Sanchez de [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-02T18:52:04Z
dc.date.available2020-07-02T18:52:04Z
dc.date.issued2018
dc.description.abstractEctopic thyroid results from a migration defect of the developing gland during embryogenesis causing congenital hypothyroidism. But it has also been detected in asymptomatic individuals. This study aimed to investigate the histopathological, functional, and genetic features of human ectopic thyroids. Six samples were histologically examined, and the expression of the specific thyroid proteins was assessed by immunohistochemistry. Two samples were submitted to whole exome sequencing. An oropharynx sample showed immature fetal architecture tissue with clusters or cords of oval thyrocytes and small folliclesen
dc.description.abstractone sample exhibited a normal thyroid pattern while four showed colloid goiter. All ectopic thyroids expressed the specific thyroid genes and T4 at similar locations to those observed in normal thyroid. No somatic mutations associated with ectopic thyroid were found. This is the first immature thyroid fetal tissue observed in an ectopic thyroid due to the arrest of structural differentiation early in the colloid stage of development that proved able to synthesize thyroid hormone but not to respond to TSH. Despite the ability of all ectopic thyroids to synthetize specific thyroid proteins and T4, at some point in life, it may be insufficient to support body growth leading to hypothyroidism, as observed in some of the patients.en
dc.description.affiliationUniv Sao Paulo FMUSP, Fac Med, Cellular & Mol Endocrine Lab, Thyroid Unit,LIM 25, Ave Doutor Arnaldo 455, BR-01246904 Sao Paulo, SP, Brazil
dc.description.affiliationSao Paulo Publ Hlth Serv, Adolfo Lutz Inst, Av Dr Arnaldo 355, BR-01246000 Sao Paulo, SP, Brazil
dc.description.affiliationHead & Neck Surg Santa Catarina Hosp, Av Paulista 200, BR-01310000 Sao Paulo, SP, Brazil
dc.description.affiliationUNESP, Botucatu Sch Med, Dept Internal Med, Av Prof Montenegro,S-N Dist Rubiao Jr, BR-18618687 Botucatu, SP, Brazil
dc.description.affiliationHosp Pediat Dr Juan Garrahan, Serv Endocrinol, Combate Pozos 1881,C1245AAM, Buenos Aires, DF, Argentina
dc.description.affiliationUniv Estadual Campinas, Fac Ciencias Med, Dept Cirurgia, Disciplina Cirurgia Cabeca & Pescoco, R Tessalia Vieira Camargo 126, BR-13083887 Campinas, SP, Brazil
dc.description.affiliationUniv Fortaleza Unifor, Med Sch, Av Washington Soares 1321, BR-60811905 Fortaleza, CE, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Postgrad Program Biotechnol, Pedro Toledo 669, BR-04039903 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Postgrad Programs Biotechnol & Struct & Funct Bio, Dept Ciencias Biol, Thyroid Mol Sci Lab,UNIFESP, Pedro Toledo 669, BR-04039903 Sao Paulo, SP, Brazil
dc.description.affiliationHosp Sirio Libanes, Mol Oncol Ctr, Rua Prof Daher Cutait 69, BR-01308060 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Postgrad Program Biotechnol, Pedro Toledo 669, BR-04039903 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Postgrad Programs Biotechnol & Struct & Funct Bio, Dept Ciencias Biol, Thyroid Mol Sci Lab,UNIFESP, Pedro Toledo 669, BR-04039903 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipInstituto da Tiroide
dc.description.sponsorshipIDFAPESP: 2009/53840-0
dc.description.sponsorshipIDFAPESP: 2010/12005-9
dc.description.sponsorshipIDFAPESP: 2014/24549-4
dc.format.extent-
dc.identifierhttps://dx.doi.org/10.1155/2018/4682876
dc.identifier.citationInternational Journal Of Endocrinology. London, v. , p. -, 2018.
dc.identifier.doi10.1155/2018/4682876
dc.identifier.fileWOS000425414300001.pdf
dc.identifier.issn1687-8337
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53866
dc.identifier.wosWOS:000425414300001
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofInternational Journal Of Endocrinology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleHistopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patienten
dc.typeinfo:eu-repo/semantics/article
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