Age-related upper limits of normal for maximum upright exercise pulmonary haemodynamics

Página do item simplificado
dc.citation.issue4
dc.citation.volume47
dc.contributor.authorOliveira, Rudolf Krawczenko Feitoza de [UNIFESP]
dc.contributor.authorAgarwal, Manyoo
dc.contributor.authorTracy, Julie A.
dc.contributor.authorKarin, Abbey L.
dc.contributor.authorOpotowsky, Alexander R.
dc.contributor.authorWaxman, Aaron B.
dc.contributor.authorSystrom, David M.
dc.coverageSheffield
dc.date.accessioned2020-07-22T13:23:10Z
dc.date.available2020-07-22T13:23:10Z
dc.date.issued2016
dc.description.abstractThe exercise definition of pulmonary hypertension was eliminated from the pulmonary hypertension guidelines in part due to uncertainty of the upper limits of normal (ULNs) for exercise haemodynamics in subjects >50 years old. The present study, therefore, evaluated the pulmonary haemodynamic responses to maximum upright incremental cycling exercise in consecutive subjects who underwent an invasive cardiopulmonary exercise testing for unexplained exertional intolerance, deemed normal based on preserved exercise capacity and normal resting supine haemodynamics. Subjects aged >50 years old (n=41) were compared with subjects. 50 years old (n=25). ULNs were calculated as mean+2SD. Peak exercise mean pulmonary arterial pressure was not different for subjects >50 and <= 50 years old (23 +/- 5 versus 22 +/- 4 mmHg, p=0.22), with ULN of 33 and 30 mmHg, respectively. Peak cardiac output was lower in older subjects (median (interquartile range): 12.1 (9.4-14.2) versus 16.2 (13.8-19.2) L.min(-1), p<0.001). Peak pulmonary vascular resistance was higher in older subjects compared with younger subjects (mean +/- SD: 1.20 +/- 0.45 versus 0.82 +/- 0.26 Wood units, p<0.001), with ULN of 2.10 and 1.34 Wood units, respectively. We observed that subjects >50 and <= 50 years old have different pulmonary vascular responses to exercise. Older subjects have higher pulmonary vascular resistance at peak exercise, resulting in different exercise haemodynamics ULNs compared with the younger population.en
dc.description.affiliationBrigham & Womens Hosp, Dept Med, Div Pulm & Crit Care Med, Boston, MA 02115 USA
dc.description.affiliationHarvard Med Sch, Boston, MA USA
dc.description.affiliationBrigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Div Resp Dis, Sao Paulo, SP, Brazil
dc.description.affiliationBoston Childrens Hosp, Dept Cardiol, Boston, MA USA
dc.description.affiliationBrigham & Womens Hosp, Dept Med, Div Cardiovasc Med, Boston, MA 02115 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Med, Div Resp Dis, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipNIH
dc.description.sponsorshipDunlevie Family Fund
dc.description.sponsorshipIDFAPESP: 2014/12212-5
dc.description.sponsorshipIDNIH: 2R01HL060234-12A1
dc.description.sponsorshipIDNIH: U01HL125215-01
dc.format.extent1179-1188
dc.identifierhttp://dx.doi.org/10.1183/13993003.01307-2015
dc.identifier.citationEuropean Respiratory Journal. Sheffield, v. 47, n. 4, p. 1179-1188, 2016.
dc.identifier.doi10.1183/13993003.01307-2015
dc.identifier.issn0903-1936
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56066
dc.identifier.wosWOS:000385955400025
dc.language.isoeng
dc.language.isopor
dc.publisherEuropean Respiratory Soc Journals Ltd
dc.relation.ispartofEuropean Respiratory Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleAge-related upper limits of normal for maximum upright exercise pulmonary haemodynamicsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos