Terpinen-4-ol, tyrosol, and beta-lapachone as potential antifungals against dimorphic fungi

Página do item simplificado
dc.citation.issue4
dc.citation.volume47
dc.contributor.authorNogueira Brilhante, Raimunda Samia
dc.contributor.authorCaetano, Erica Pacheco
dc.contributor.authorChaves de Lima, Rita Amanda
dc.contributor.authorde Farias Marques, Francisca Jakelyne
dc.contributor.authorCollares Maia Castelo-Branco, Debora de Souza
dc.contributor.authorSilva de Melo, Charlline Vladia
dc.contributor.authorde Melo Guedes, Glaucia Morgana
dc.contributor.authorde Oliveira, Jonathas Sales
dc.contributor.authorCamargo, Zoilo Pires de [UNIFESP]
dc.contributor.authorBezerra Moreira, Jose Luciano
dc.contributor.authorMonteiro, Andre Jalles
dc.contributor.authorPinheiro Gomes Bandeira, Tereza de Jesus
dc.contributor.authorCordeiro, Rossana de Aguiar
dc.contributor.authorGadelha Rocha, Marcos Fabio
dc.contributor.authorCosta Sidrim, Jose Julio
dc.coverageSao Paulo
dc.date.accessioned2020-07-31T12:47:38Z
dc.date.available2020-07-31T12:47:38Z
dc.date.issued2016
dc.description.abstractThis study aimed to evaluate the in vitro antifungal activity of terpinen-4-ol, tyrosol, and beta-lapachone against strains of Coccidioides posadasii in filamentous phase (n=22) and Histoplasma capsulatum in both filamentous (n=40) and yeast phases (n=13), using the broth dilution methods as described by the Clinical and Laboratory Standards Institute, to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of these compounds. The mechanisms of action of these compounds were also investigated by analyzing their effect on cell membrane permeability and ergosterol synthesis. The MIC and MFCf these compounds against C. posadasii, mycelial H. capsulatum, and yeast-like H. capsulatum, were in the following ranges: 350-5720 mu g/mL, 20-2860 mu g/mL, and 40-1420 mu g/mL, respectively for terpinen-4-olen
dc.description.abstract250-4000 mu g/mL, 30-2000 mu g/mL, and 10-1000 mu g/mL, respectively, for tyrosolen
dc.description.abstractand 0.48-7.8 mu g/mL, 0.25-16 mu g/mL, and 0.125-4 mu g/mL, respectively for p-lapachone. These compounds showed a decrease in MIC when the samples were subjected to osmotic stress, suggesting that the compounds acted on the fungal membrane. All the compounds were able to reduce the ergosterol content of the fungal strains. Finally, tyrosol was able to cause a leakage of intracellular molecules. (C) 2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda.en
dc.description.affiliationUniv Fed Ceara, Postgrad Program Med Microbiol, Specialized Med Mycol Ctr, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Ceara, Postgrad Program Med Sci, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Cellular Biol Div, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Ceara, Dept Stat & Appl Math, Fortaleza, Ceara, Brazil
dc.description.affiliationChristus Coll Unichristus, Sch Med, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Estadual Ceara, Postgrad Program Vet Sci, Fortaleza, Ceara, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo (UNIFESP), Department of Microbiology, Immunology and Parasitology, Cellular Biology Division, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDCNPq: 303396/2014-8
dc.description.sponsorshipIDCNPq: 552161/2011-0
dc.description.sponsorshipIDCAPES: AE1-0052-000630100/11
dc.format.extent917-924
dc.identifierhttp://dx.doi.org/10.1016/j.bjm.2016.07.015
dc.identifier.citationBrazilian Journal Of Microbiology. Sao Paulo, v. 47, n. 4, p. 917-924, 2016.
dc.identifier.doi10.1016/j.bjm.2016.07.015
dc.identifier.fileS1517-83822016000400917.pdf
dc.identifier.issn1517-8382
dc.identifier.scieloS1517-83822016000400917
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56960
dc.identifier.wosWOS:000388619600020
dc.language.isoeng
dc.publisherSoc Brasileira Microbiologia
dc.relation.ispartofBrazilian Journal Of Microbiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDimorphic fungien
dc.subjectTerpinen-4-olen
dc.subjectTyrosolen
dc.subjectbeta-Lapachoneen
dc.subjectInhibitory effecten
dc.titleTerpinen-4-ol, tyrosol, and beta-lapachone as potential antifungals against dimorphic fungien
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S1517-83822016000400917.pdf
Tamanho:
858.06 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos