Sympathetic overactivity occurs before hypertension in the two-kidney, one-clip model

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dc.contributor.authorOliveira-Sales, Elizabeth Barbosa de [UNIFESP]
dc.contributor.authorColombari, Eduardo
dc.contributor.authorAbdala, Ana Paula Lima [UNIFESP]
dc.contributor.authorCampos, Ruy Ribeiro [UNIFESP]
dc.contributor.authorPaton, Julian Francis Richmond
dc.date.accessioned2019-01-21T10:30:15Z
dc.date.available2019-01-21T10:30:15Z
dc.date.issued2016
dc.description.abstractOur knowledge of mechanisms responsible for both the development and the maintenance of hypertension remains incomplete in the Goldblatt (two-kidney, one-clipen
dc.description.abstract2K1C) model. We tested the hypothesis that elevated sympathetic nerve activity (SNA) occurs before the onset of hypertension in 2K1C rats, considering the time course of the increase in SNA in relationship to the onset of the hypertension. We used a decorticated in situ working heart-brainstem preparation of three groups of male Wistar rats, namely sham-operated animals (SHAM, n = 7) and animals 3 weeks post-2K1C, of which some were hypertensive (2K1C-H, n = 6) and others normotensive (2K1C-N, n = 9), as determined in vivo a priori. Perfusion pressure was higher in both 2K1C groups (2K1C-H, 76 +/- 1 mmHgen
dc.description.abstract2K1C-N, 74 +/- 3 mmHgen
dc.description.abstractversus SHAM, 60 +/- 2 mmHg, P < 0.05). The SNA was significantly elevated in both 2K1C groups (2K1C-H, 47.7 +/- 6.1 mu Ven
dc.description.abstract2K1C-N, 32.8 +/- 2.8 mu Ven
dc.description.abstractversus SHAM, 20.5 +/- 2.5 mu V, P < 0.05) owing to its increased respiratory modulationen
dc.description.abstractthe chemoreflex was augmented and baroreflex depressed. Precollicular transection reduced SNA in all groups (2K1C-H, -32.5 +/- 7.5%en
dc.description.abstract2K1C-NH, -48 +/- 6.9%en
dc.description.abstractversus SHAM, -13.2 +/- 1%, P < 0.05). Subsequent medullary spinal cord transection abolished SNA in both SHAM and 2K1C-N groups, but decreased it by only 57 +/- 5.5% in 2K1C-H preparations. Thus, SNA is raised before the onset of hypertension, by the third week after renal artery clipping, and this originates, in part, from its enhanced respiratory modulation. Spinal circuits contribute to the elevation of SNA in the 2K1C model, but only after hypertension has developed.en
dc.description.affiliationSchool of Physiology & Pharmacology, Bristol Heart Institute, University of Bristol, Bristol, UK
dc.description.affiliationDepartment of Physiology, Federal University of Sao Paulo, UNIFESP, SP, Brazil
dc.description.affiliationDepartment of Physiology & Pathology, School of Dentistry of Araraquara, São Paulo State University, UNESP, Araraquara, SP, Brazil
dc.description.affiliationUnifespDepartment of Physiology, Federal University of Sao Paulo, UNIFESP, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenacao de Aperfeicoamento de pessoal de Nivel Superior (CAPES, Brazil) [3496/07-4]
dc.description.sponsorshipBritish Heart Foundation [RG/12/6/29670]
dc.description.sponsorshipNational Institutes of Health [RO1 NS069220]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) from Brazil
dc.description.sponsorshipBenjamin Meaker Fellowship from the University of Bristol
dc.description.sponsorshipRoyal Society Wolfson Research Merit Award
dc.description.sponsorshipIDCAPES: 3496/07-4
dc.description.sponsorshipIDBritish Heart Foundation: RG/12/6/29670
dc.description.sponsorshipIDNational Institutes of Health: RO1 NS069220
dc.format.extent67-80
dc.identifierhttps://doi.org/10.1113/EP085390
dc.identifier.citationExperimental Physiology. Hoboken, v. 101, n. 1, p. 67-80, 2016.
dc.identifier.doi10.1113/EP085390
dc.identifier.issn0958-0670
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49659
dc.identifier.wosWOS:000368251900010
dc.language.isoeng
dc.publisherWiley-blackwell
dc.relation.ispartofExperimental Physiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRostral Ventrolateral Medullaen
dc.subjectCirculating Angiotensin-Iien
dc.subjectNucleus-Tractus-Solitariien
dc.subjectNervous-System Activityen
dc.subjectBrain-Stem Preparationen
dc.subjectRat Carotid-Bodyen
dc.subjectRenovascular Hypertensionen
dc.subjectRenal Denervationen
dc.subjectNeurogenic Hypertensionen
dc.subjectGoldblatt Hypertensionen
dc.titleSympathetic overactivity occurs before hypertension in the two-kidney, one-clip modelen
dc.typeinfo:eu-repo/semantics/article
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