Stress during development alters anxiety-like behavior and hippocampal neurotransmission in male and female rats

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dc.contributor.authorBarbosa Neto, Jair B. [UNIFESP]
dc.contributor.authorTiba, Paula A. [UNIFESP]
dc.contributor.authorFaturi, Claudia B. [UNIFESP]
dc.contributor.authorCastro-Neto, Eduardo F. de [UNIFESP]
dc.contributor.authorNaffah-Mazacoratti, Maria da Graca [UNIFESP]
dc.contributor.authorMaria, Jair de Jesus [UNIFESP]
dc.contributor.authorMello, Marcelo F. de [UNIFESP]
dc.contributor.authorSuchecki, Deborah [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2016-01-24T14:17:43Z
dc.date.available2016-01-24T14:17:43Z
dc.date.issued2012-01-01
dc.description.abstractEpidemiological data indicate that early stress increases vulnerability to psychiatric disorders, including anxiety and depression. in the present study we sought to investigate the long-term behavioral and neurochemical consequences of increased and sustained corticosterone levels induced by a 24 h bout of maternal deprivation (DEP) imposed on postnatal day 11 (DEP11). As adults, animals were exposed to the elevated plus maze for assessment of anxiety-like behavior and corticosterone response to this challenge, or decapitated for determination of monoamines and amino acid neurotransmitters content in the hippocampus by HPLC method. the results showed that DEP11 male and female rats displayed increased time in the central hub of the maze and more risk assessment behavior, reflecting increased anxiety-like behavior; in addition, these animals continuously secreted corticosterone in response to the behavioral test until the latest time-point, e.g., 60 min post-stress. in males, maternal deprivation increased aspartate and glutamate levels and reduced taurine levels compared to non-deprived (NDEP) rats. DEP11 females displayed reduced noradrenaline, aspartate and GABA levels compared to NDEP counterparts. These results indicate that maternal deprivation at 11 days of age produced changes in hippocampal neurotransmission that may mediate the increased anxiety-like behavior observed in male and female deprived rats.This article is part of a Special Issue entitled 'Anxiety and Depression'. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psiquiatria, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Expt Neurol, São Paulo, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Matemat Comp & Cognicao, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psiquiatria, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Expt Neurol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipINNT
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipCInNAPCe
dc.description.sponsorshipAssociacao Fundo de Incentivo a Psicofarmacologia (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2004/15039-0
dc.description.sponsorshipIDFAPESP: 2006/06415-4
dc.format.extent518-526
dc.identifierhttp://dx.doi.org/10.1016/j.neuropharm.2011.09.011
dc.identifier.citationNeuropharmacology. Oxford: Pergamon-Elsevier B.V., v. 62, n. 1, p. 518-526, 2012.
dc.identifier.doi10.1016/j.neuropharm.2011.09.011
dc.identifier.issn0028-3908
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34459
dc.identifier.wosWOS:000296826800056
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuropharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectMaternal deprivationen
dc.subjectAnxiety-like behavioren
dc.subjectStressen
dc.subjectHippocampusen
dc.subjectHPLCen
dc.subjectTaurineen
dc.subjectGABAen
dc.titleStress during development alters anxiety-like behavior and hippocampal neurotransmission in male and female ratsen
dc.typeinfo:eu-repo/semantics/article
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