DNA damage in multiple organs after exposure to chlorhexidine in Wistar rats

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dc.contributor.authorGrassi, Tony Fernando
dc.contributor.authorCamargo, Elaine Aparecida de
dc.contributor.authorSalvadori, Daisy Maria Favero
dc.contributor.authorMarques, Mariangela Esther Alencar
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T12:41:56Z
dc.date.available2016-01-24T12:41:56Z
dc.date.issued2007-03-01
dc.description.abstractSince chlorhexidine is effective against microorganisms, it is widely recommended in dentistry. However, studies have provided evidence that chlorhexidine is toxic for a variety of cell types. in order to identify potential genotoxins in different cell types, the purpose of this study was to investigate whether chlorhexidine digluconate is able to cause, in terms of DNA damage, alterations in leukocytes, liver, kidney and urinary bladder by the single cell gel (comet) assay. Ten male Wistar rats were divided into two groups: a negative control and the experimental group treated with 3 ml of 0.12% chlorhexidine digluconate by gavage once a day for 8 days. Statistically significant increases of DNA damage was observed in leukocytes and kidney cells of the chlorhexidine digluconate treated group as depicted by the mean tail moment. Taken together, the data indicate that leukocytes and kidney cells are potential targets for primary DNA damage following oral exposure to chlorhexidine digluconate as detected by single cell gel (comet) assay. (c) 2006 Elsevier GmbH. All rights reserved.en
dc.description.affiliationUNIFESP, Dept Ciencias Saude, Santos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med Botucatu, Dept Patol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnifespUNIFESP, Dept Ciencias Saude, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent163-167
dc.identifierhttps://dx.doi.org/10.1016/j.ijheh.2006.09.001
dc.identifier.citationInternational Journal of Hygiene and Environmental Health. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 210, n. 2, p. 163-167, 2007.
dc.identifier.doi10.1016/j.ijheh.2006.09.001
dc.identifier.issn1438-4639
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/29551
dc.identifier.wosWOS:000244785400009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Hygiene and Environmental Health
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectChlorhexidineen
dc.subjectDNA damageen
dc.subjectKidneyen
dc.subjectLiveren
dc.subjectSingle cell gel (comet) assayen
dc.subjectUrinary bladderen
dc.titleDNA damage in multiple organs after exposure to chlorhexidine in Wistar ratsen
dc.typeinfo:eu-repo/semantics/article
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