A schizophrenia-like behavioral trait in the SHR model: Applying confirmatory factor analysis as a new statistical tool

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dc.contributor.authorPeres, Fernanda Fiel [UNIFESP]
dc.contributor.authorEufrasio, Rai Alvares [UNIFESP]
dc.contributor.authorGouvea, Douglas Albuquerque [UNIFESP]
dc.contributor.authorDian, Mariana Cepollaro [UNIFESP]
dc.contributor.authorSantos, Camila Mauricio [UNIFESP]
dc.contributor.authorSwardfager, Walter
dc.contributor.authorAbilio, Vanessa Costhek [UNIFESP]
dc.contributor.authorCogo-Moreira, Hugo [UNIFESP]
dc.date.accessioned2018-07-26T12:18:25Z
dc.date.available2018-07-26T12:18:25Z
dc.date.issued2018
dc.description.abstractQuestionnaires that assess symptoms of schizophrenia patients undergo strict statistical validation, often using confirmatory factor analysis (CFA). CFA allows testing the existence of a trait that both collectively explains the symptoms and gathers the information in a single general index. In rodents, some behaviors are used to model psychiatric symptoms, but no single test or paradigm adequately captures the disorder's phenotype in toto. This work investigated the existence of a behavioral trait in the SHR strain underlying five behavioral tasks used in schizophrenia animal studies and altered in this strain: locomotor activity, rearing behavior, social interaction, prepulse inhibition of startle and contextual fear conditioning. The analysis was conducted on a sample of Wistar (n= 290) and Spontaneously Hypertensive Rats (SHRs, n= 290). CFA showed the existence of a continuous trait in both strains, and higher values among SHRs. This work is the first to demonstrate the existence of a schizophrenia-like trait in an animal model. We suggest that using CFA to evaluate behavioral parameters in animals might facilitate the pre-clinical investigation of psychiatric disorders, diminishing the gap between animal and human studies.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat & Med Psychol, Interdisciplinary Lab Clin Neurosci, LiNC, Sao Paulo, Brazil
dc.description.affiliationCAPES, FAPESP, CNPq, Natl Inst Translat Med,INCT TM, Ribeirao Preto, Brazil
dc.description.affiliationUniv Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada
dc.description.affiliationSunnybrook Res Inst, Hurvitz Brain Sci Program, Toronto, ON, Canada
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat & Med Psychol, Interdisciplinary Lab Clin Neurosci, LiNC, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent16-22
dc.identifierhttp://dx.doi.org/10.1016/j.pnpbp.2018.03.021
dc.identifier.citationProgress In Neuro-Psychopharmacology & Biological Psychiatry. Oxford, v. 85, p. 16-22, 2018.
dc.identifier.doi10.1016/j.pnpbp.2018.03.021
dc.identifier.issn0278-5846
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45961
dc.identifier.wosWOS:000432864900003
dc.language.isoeng
dc.publisherPergamon-Elsevier Science Ltd
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectConfirmatory factor analysisen
dc.subjectAnimal modelen
dc.subjectSchizophreniaen
dc.subjectSpontaneously hypertensive raten
dc.subjectLatent traiten
dc.titleA schizophrenia-like behavioral trait in the SHR model: Applying confirmatory factor analysis as a new statistical toolen
dc.typeinfo:eu-repo/semantics/article
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