Crystal growth of progesterone metastable and stable polymorphs by polymer induced herteronucleation (pihn) method

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dc.contributor.authorAraya-Sibaja, Andrea Mariela
dc.contributor.authorSoldi, Valdir
dc.contributor.authorMaduro de Campos, Carlos Eduardo
dc.contributor.authorCardoso, Simone Goncalves
dc.contributor.authorCuffini, Silvia Lucia [UNIFESP]
dc.date.accessioned2019-01-21T10:30:13Z
dc.date.available2019-01-21T10:30:13Z
dc.date.issued2016
dc.description.abstractThe selective crystallization of progesterone polymorphs prepared by Polymer-Induced Heteronucleation (PIHn) method was investigated. Polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), dextran, gelatin, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as heteronucleants. Crystallizations were conducted from 0.5,10 and 40 mg mL(-1) solutions in chloroform at room temperature by solvent evaporation. The samples were characterized by X-ray powder diffraction, differential scanning calorimetry, infrared spectroscopy and scanning electron microscopy. Form 2 was obtained from 0.5 mg mL(-1) solution in almost all polymers. A mixture of both poly morphs crystallized from the three concentrations on gelatineen
dc.description.abstractfrom 10 and 40mg mL(-1) on PVA and HPMC and, from 10 mg mL(-1) solutions on NBR. Form 2 crystallized on HPMC was stable for three months under ambient stress conditions (40 degrees C and 75% RH). These results are good evidence that the tailoring of new formulations and devices with progesterone the metastable and more soluble form 2 is possible.en
dc.description.affiliationEscuela de Química, Universidad de Costa Rica, San José, Costa Rica
dc.description.affiliationGrupo de estudo em materiais poliméricos (POLIMAT), Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, Brasil
dc.description.affiliationPrograma de Pós‐Graduação em Física, Universidade Federal de Santa Catarina, Florianópolis, Brasil
dc.description.affiliationPrograma de Pós‐Graduação em Farmácia, Universidade Federal de Santa Catarina, Florianópolis, Brasil
dc.description.affiliationInstituto de Ciência e Tecnologia, Universidade Federal de São Paulo, São José dos Campos, São Paulo, Brasil
dc.description.affiliationUnifespInstituto de Ciência e Tecnologia, Universidade Federal de São Paulo, São José dos Campos, São Paulo, Brasil
dc.description.sourceWeb of Science
dc.description.sponsorshipCNPq
dc.description.sponsorshipCAPES
dc.description.sponsorshipFAPESC
dc.description.sponsorshipCLAF
dc.description.sponsorshipCONICET
dc.description.sponsorshipLaboratorio de Difracao de Raio-X (LDRX)
dc.description.sponsorshipLaboratorio Central de Microscopia Eletronica (LCME) at UFSC
dc.description.sponsorshipCONICET, Argentina
dc.description.sponsorshipConsejo Superior de Investigaciones Cientificas (CSIC) of Spain
dc.description.sponsorshipFundacion Sauberan
dc.format.extent49-57
dc.identifierhttps://doi.org/10.1002/crat.201500145
dc.identifier.citationCrystal Research And Technology. Weinheim, v. 51, n. 1, p. 49-57, 2016.
dc.identifier.doi10.1002/crat.201500145
dc.identifier.issn0232-1300
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49640
dc.identifier.wosWOS:000368703100007
dc.language.isoeng
dc.publisherWiley-v c h verlag gmbh
dc.relation.ispartofCrystal Research And Technology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCrystal Growthen
dc.subjectProgesterone Polymorphsen
dc.subjectPolymer Induced Heteronucleationen
dc.subjectStability StudyDiscoveryen
dc.subjectTransformationen
dc.subjectHeteronucleien
dc.subjectSolubilityen
dc.subjectProgestinsen
dc.subjectSelectionen
dc.titleCrystal growth of progesterone metastable and stable polymorphs by polymer induced herteronucleation (pihn) methoden
dc.typeinfo:eu-repo/semantics/article
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