Immediate versus delayed treatment for recently symptomatic carotid artery stenosis

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dc.contributor.authorVasconcelos, Vladimir [UNIFESP]
dc.contributor.authorCassola, Nicolle [UNIFESP]
dc.contributor.authorda Silva, Edina M. K.
dc.contributor.authorBaptista-Silva, Jose C. C. [UNIFESP]
dc.date.accessioned2019-01-21T10:29:41Z
dc.date.available2019-01-21T10:29:41Z
dc.date.issued2016
dc.description.abstractBackground The timing of surgery for recently symptomatic carotid artery stenosis remains controversial. Early cerebral revascularization may prevent a disabling or fatal ischemic recurrence, but it may also increase the risk of hemorrhagic transformation, or of dislodging a thrombus. This review examined the randomized controlled evidence that addressed whether the increased risk of recurrent events outweighed the increased benefit of an earlier intervention. Objectives To assess the risks and benefits of performing very early cerebral revascularization (within two days) compared with delayed treatment (after two days) for people with recently symptomatic carotid artery stenosis. Search methods We searched the Cochrane Stroke Group Trials Register in January 2016, the Cochrane Central Register of Controlled Trials (CENTRALen
dc.description.abstractThe Cochrane Library 2016, Issue 1), MEDLINE (1948 to 26 January 2016), EMBASE (1974 to 26 January 2016), LILACS (1982 to 26 January 2016), and trial registers (from inception to 26 January 2016). We also handsearched conference proceedings and journals, and searched reference lists. There were no language restrictions. We contacted colleagues and pharmaceutical companies to identify further studies and unpublished trials. Selection criteria All completed, truly randomized trials (RCT) that compared very early cerebral revascularization (within two days) with delayed treatment (after two days) for people with recently symptomatic carotid artery stenosis. Data collection and analysis We independently selected trials for inclusion according to the above criteria, assessed risk of bias for each trial, and performed data extraction. We utilized an intention-to-treat analysis strategy. Main results We identified one RCT that involved 40 participants, and addressed the timing of surgery for people with recently symptomatic carotid artery stenosis. It compared very early surgery with surgery performed after 14 days of the last symptomatic event. The overall quality of the evidence was very low, due to the small number of participants from only one trial, and missing outcome data. We found no statistically significant difference between the effects of very early or delayed surgery in reducing the combined risk of stroke and death within 30 days of surgery (risk ratio (RR) 3.32en
dc.description.abstractconfidence interval (CI) 0.38 to 29.23en
dc.description.abstractvery low-quality evidence), or the combined risk of perioperative death and stroke (RR 0.47en
dc.description.abstractCI 0.14 to 1.58en
dc.description.abstractvery low-quality evidence). To date, no results are available to confirm the optimal timing for surgery. Authors' conclusions There is currently no high-quality evidence available to support either very early or delayed cerebral revascularization after a recent ischemic stroke. Hence, further randomized trials to identify which patients should undergo very urgent revascularization are needed. Future studies should stratify participants by age group, sex, grade of ischemia, and degree of stenosis. Currently, there is one ongoing RCT that is examining the timing of cerebral revascularization.en
dc.description.affiliationDepartment of Vascular Surgery, Universidade Federal de São Paulo, Rua Borges Lagoa 754, BR-04038001 Sao Paulo, Brazi
dc.description.affiliationEmergency Medicine and Evidence BasedMedicine, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationEvidence Base d Medicine, Cochrane Brazil, Universidade Federal deSão Paulo, São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Vascular Surgery, Universidade Federal de São Paulo, Rua Borges Lagoa 754, BR-04038001 Sao Paulo, Brazi
dc.description.affiliationUnifespEmergency Medicine and Evidence BasedMedicine, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespEvidence Base d Medicine, Cochrane Brazil, Universidade Federal deSão Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCochrane Stroke Group, UK
dc.description.sponsorshipDepartment of emergency Medicine of Universidade Federal de Sao Paulo, UNIFESP, Brazil
dc.description.sponsorshipBrazilian Cochrane Center, Brazil
dc.format.extentCD011401
dc.identifierhttp://dx.doi.org/10.1002/14651858.CD011401.pub2
dc.identifier.citationCochrane Database Of Systematic Reviews. Hoboken, n. 9, p. CD011401, 2016.
dc.identifier.doi10.1002/14651858.CD011401.pub2
dc.identifier.fileWOS000389599000018.pdf
dc.identifier.issn1469-493X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49328
dc.identifier.wosWOS:000389599000018
dc.language.isoeng
dc.publisherHindawi Publishing Corp
dc.relation.ispartofCochrane Database Of Systematic Reviews
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTransient Ischemic Attacken
dc.subjectVascular-Surgery Guidelinesen
dc.subjectProcedural Risken
dc.subjectFlow Reversalen
dc.subjectAcute Strokeen
dc.subjectEndarterectomyen
dc.subjectMulticenteren
dc.subjectMetaanalysisen
dc.subjectEvolutionen
dc.subjectSocietyen
dc.titleImmediate versus delayed treatment for recently symptomatic carotid artery stenosisen
dc.typeinfo:eu-repo/semantics/review
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