TNF-α and IL-6 immunohistochemistry in rat renal tissue experimentaly infected with Leptospira interrogans serovar Canicola

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dc.contributor.authorMarinho, Márcia
dc.contributor.authorMonteiro, Cristina Maria Rodrigues
dc.contributor.authorPeiró, Jr
dc.contributor.authorMachado, Gf
dc.contributor.authorOliveira-Júnior, Itamar Souza [UNIFESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:38:17Z
dc.date.available2015-06-14T13:38:17Z
dc.date.issued2008-01-01
dc.description.abstractLeptospirosis is a public health problem worldwide and its etiology remains unclear. Its pathogenesis involves a complex interaction between host and infecting microorganism. The inflammatory reaction that controls the infection process also underscores many pathophysiological events occurring in leptospirosis. We investigated the presence of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in renal tissues by immunohistochemical and histopathological examination in animals experimentally inoculated with Leptospira serovar Canicola. All the tests were carried out 2, 7, 14, 21 or 28 days after inoculation. Although TNF-α and IL-6 had been detected in tissues throughout the observation period, these cytokines appeared more intensely during the initial phase of infection. Therefore, both TNF-α and IL-6 were associated with the immunopathogenesis of leptospirosis. This profile suggests a high immunocellular response throughout the early infection stages followed by subsequent humoral response.en
dc.description.affiliationSão Paulo State University Dentistry School Department of Animal Health and Production
dc.description.affiliationSão Paulo State University Dentistry School Department of Clinics, Surgery and Animal Reproduction
dc.description.affiliationFederal University of São Paulo Department of Medicine
dc.description.affiliationUnifespUNIFESP, Department of Medicine
dc.description.sourceSciELO
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent533-540
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992008000300012
dc.identifier.citationJournal of Venomous Animals and Toxins including Tropical Diseases. Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, v. 14, n. 3, p. 533-540, 2008.
dc.identifier.doi10.1590/S1678-91992008000300012
dc.identifier.fileS1678-91992008000300012.pdf
dc.identifier.issn1678-9199
dc.identifier.scieloS1678-91992008000300012
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/4149
dc.identifier.wosWOS:000259279500012
dc.language.isoeng
dc.publisherCentro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP
dc.relation.ispartofJournal of Venomous Animals and Toxins including Tropical Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectleptospirosisen
dc.subjectimmunohistochemistryen
dc.subjectIL-6en
dc.subjectTNF-αen
dc.subjectmiceen
dc.titleTNF-α and IL-6 immunohistochemistry in rat renal tissue experimentaly infected with Leptospira interrogans serovar Canicolaen
dc.typeinfo:eu-repo/semantics/article
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