Reduced urinary excretion of sulfated polysaccharides in diabetic rats

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dc.contributor.authorLima, Cilene Rebouças de [UNIFESP]
dc.contributor.authorAguiar, Jair Adriano Kopke [UNIFESP]
dc.contributor.authorMichelacci, Yara Maria [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:55Z
dc.date.available2016-01-24T12:37:55Z
dc.date.issued2005-06-30
dc.description.abstractThe aim of the present study was to further understand the changes in renal filtration that occur in the early stages of diabetes mellitus. Diabetes was induced in male Wistar rats by a single injection of streptozotocin. Glycemia, body weight, 24-h urine volume and urinary excretion of creatinine, protein and glycosaminoglycans were measured 10 and 30 days after diabetes induction. All the diabetic animals used in the present study were hyperglycemic, did not gain weight, and presented proteinuria and creatinine hyperfiltration. in contrast, the glycosaminoglycan excretion decreased. Dextrain sulfates of different molecular weights (6.0 to 11.5 kDa) were administered to the diabetic rats, and to age-matched, sham-treated controls. Most of the dextran sulfate was excreted during the first 24 h, and the amounts excreted in the urine were inversely proportional to the dextran sulfate molecular weight for all groups. Nevertheless, diabetic rats excreted less and accumulated more dextran sulfate in kidney and liver, as compared to controls. These differences, which were observed only for the dextran sulfates of higher molecular weights (> 7 kDa), increased with the duration of diabetes. Our findings suggest differential renal processing mechanisms for proteins and sulfated polysaccharides, with the possible involvement of kidney cells. (c) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, EPM, Dept Bioquim, UNIFESP, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, Dept Bioquim, UNIFESP, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent30-41
dc.identifierhttp://dx.doi.org/10.1016/j.bbadis.2004.10.001
dc.identifier.citationBiochimica Et Biophysica Acta-molecular Basis of Disease. Amsterdam: Elsevier B.V., v. 1741, n. 1-2, p. 30-41, 2005.
dc.identifier.doi10.1016/j.bbadis.2004.10.001
dc.identifier.fileWOS000230255600005.pdf
dc.identifier.issn0925-4439
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28348
dc.identifier.wosWOS:000230255600005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiochimica Et Biophysica Acta-molecular Basis of Disease
dc.rightsAcesso aberto
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectdiabetes mellitusen
dc.subjectrenal filtrationen
dc.subjectdextran sulfateen
dc.subjectglycosaminoglycanen
dc.titleReduced urinary excretion of sulfated polysaccharides in diabetic ratsen
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