Role of kinin B1 and B2 receptors in memory consolidation during the aging process of mice

Página do item simplificado
dc.contributor.authorResk Lemos, Mayra Tolentino
dc.contributor.authorAmaral, Fabio Agostini
dc.contributor.authorDong, Karis Ester
dc.contributor.authorQueiroz Prado Bittencourt, Maria Fernanda
dc.contributor.authorCaetano, Ariadiny Lima
dc.contributor.authorPesquero, Joao Bosco [UNIFESP]
dc.contributor.authorViel, Tania Araujo
dc.contributor.authorBuck, Hudson Sousa
dc.contributor.institutionFac Ciencias Med Santa Casa São Paulo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:32Z
dc.date.available2016-01-24T13:59:32Z
dc.date.issued2010-04-01
dc.description.abstractUnder physiological conditions, elderly people present memory deficit associated with neuronal loss. This pattern is also associated with Alzheimer's disease but, in this case, in a dramatically intensified level. Kinin receptors have been involved in neurodegeneration and increase of amyloid-beta concentration, associated with Alzheimer's disease (AD). Considering these findings, this work evaluated the role of kinin receptors in memory consolidation during the aging process. Male C57BI/6 (wt), knock-out B1 (koB1) or B2 (koB2) mice (3, 6, 12 and 18-month-old - mo; n = 10 per group) were submitted to an acquisition session, reinforcement to learning (24 h later: test 1) and final test (7 days later: test 2), in an active avoidance apparatus, to evaluate memory. Conditioned avoidance responses (CAR, % of 50 trials) were registered. in acquisition sessions, similar CAR were obtained among age matched animals from all strains. However, a significant decrease in CAR was observed throughout the aging process (3mo: 8.8 +/- 2.3%; 6mo: 4.1 +/- 0.6%; 12mo: 2.2 +/- 0.6%, 18mo: 3.6 +/- 0.6%, P < 0.01), indicating a reduction in the learning process. in test 1, as expected, memory retention increased significantly (P < 0.05) in all 3- and 6-month-old animals as well as in 12-month-old-wt and 12-month-old-koB1 (P < 0.01), compared to the training session. However, 12-month-old-koB2 and all 18-month-old animals did not show an increase in memory retention. in test 2, 3- and 6-month-old wt and koB1 mice of all ages showed a significant improvement in memory (P < 0.05) compared to test 1. However, 12-month-old wt and koB2 mice of all ages showed no difference in memory retention. We suggest that, during the aging process, the B1 receptor could be involved in neurodegeneration and memory loss. Nevertheless, the B2 receptor is apparently acting as a neuroprotective factor. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationFac Ciencias Med Santa Casa São Paulo, Dept Physiol Sci, BR-01221020 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Arts Sci & Humanities, BR-03828000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biophys, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biophys, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent163-168
dc.identifierhttp://dx.doi.org/10.1016/j.npep.2009.12.006
dc.identifier.citationNeuropeptides. Edinburgh: Churchill Livingstone, v. 44, n. 2, p. 163-168, 2010.
dc.identifier.doi10.1016/j.npep.2009.12.006
dc.identifier.issn0143-4179
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32428
dc.identifier.wosWOS:000276001700015
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.relation.ispartofNeuropeptides
dc.rightsAcesso restrito
dc.subjectKinin receptorsen
dc.subjectAgingen
dc.subjectLearningen
dc.subjectMemoryen
dc.subjectElderlyen
dc.subjectKallikreinen
dc.titleRole of kinin B1 and B2 receptors in memory consolidation during the aging process of miceen
dc.typeArtigo
Arquivos
Coleções
EPM - Artigos