A cross-sectional study assessing the pharyngeal carriage of Neisseria meningitidis in subjects aged 1-24 years in the city of Embu das Artes, Sao Paulo, Brazil

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dc.citation.issue6
dc.citation.volume21
dc.contributor.authorWeckx, Lily Yin [UNIFESP]
dc.contributor.authorPuccini, Rosana Fiorini [UNIFESP]
dc.contributor.authorMachado, Antonia [UNIFESP]
dc.contributor.authorGoncalves, Maria Gisele
dc.contributor.authorTuboi, Suely
dc.contributor.authorde Barros, Eliana
dc.contributor.authorDevadiga, Raghavendra
dc.contributor.authorOrtega-Barria, Eduardo
dc.contributor.authorColindres, Romulo
dc.coverageRio De Janeiro
dc.date.accessioned2020-09-01T13:21:19Z
dc.date.available2020-09-01T13:21:19Z
dc.date.issued2017
dc.description.abstractMeningococcal carriage is a prerequisite for invasive infection. This cross-sectional study assessed the pharyngeal carriage prevalence in healthy subjects aged 1-24 years in Embu das Artes city, Sao Paulo, Brazil. Pharyngeal swabs were examined for the presence of Neisseria meningitidis. The isolates were tested for different serogroups using agglutination and polymerase chain reaction. A logistic regression model assessed any independent association between Neisseria meningitidis carriage and various risk factors. A total of 87/967 subjects (9%, 95% Confidence Interval (CI): 7.3-11.0) tested positive for N. meningitidis: 6.2% (95% CI: 3.8-9.4) in 1-4 years, 8.5% (95% CI: 5.1-13.0) in 5-9 years, 12.5% (95% CI: 7.8-18.6) in 10-14 years, 12.6% (95% CI: 7.4-19.7) in 15-19 years and 9% (95% CI: 4.9-14.9) in 20-24 years age groups. Highest carriage prevalence was observed in adolescents 10-19 years old. Serogroup C was predominant (18.4%) followed by serogroup B (12.6%). The 15-19 years age group showed a significant association between number of household members and carriers of N. meningitidis. This cross-sectional study is the first in Brazil to evaluate meningococcal carriage prevalence and associated factors in a wide age range. (C) 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Sao Paulo, SP, Brazil
dc.description.affiliationAdolfo Lutz Inst, Inst Immunol, Sao Paulo, SP, Brazil
dc.description.affiliationGSK Brazil, Rio De Janeiro, RJ, Brazil
dc.description.affiliationGSK, Bangalore, Karnataka, India
dc.description.affiliationGSK, Panama City, Panama
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Med, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipGlaxoSmithKline Biologicals SA
dc.format.extent587-595
dc.identifierhttp://dx.doi.org/10.1016/j.bjid.2017.06.005
dc.identifier.citationBrazilian Journal Of Infectious Diseases. Rio De Janeiro, v. 21, n. 6, p. 587-595, 2017.
dc.identifier.doi10.1016/j.bjid.2017.06.005
dc.identifier.fileS1413-86702017000600587.pdf
dc.identifier.issn1413-8670
dc.identifier.scieloS1413-86702017000600587
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58191
dc.identifier.wosWOS:000423287700003
dc.language.isoeng
dc.publisherElsevier Brazil
dc.relation.ispartofBrazilian Journal Of Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCarriageen
dc.subjectMeningococcal diseaseen
dc.subjectNeisseria meningitidisen
dc.subjectPharyngealen
dc.subjectSerogroupen
dc.titleA cross-sectional study assessing the pharyngeal carriage of Neisseria meningitidis in subjects aged 1-24 years in the city of Embu das Artes, Sao Paulo, Brazilen
dc.typeinfo:eu-repo/semantics/article
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