The Underexploited Role of Non-Coding RNAs in Lysosomal Storage Diseases

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dc.citation.volume7
dc.contributor.authorQueiroz, Matheus Trovao de [UNIFESP]
dc.contributor.authorPereira, Vanessa Goncalves [UNIFESP]
dc.contributor.authorNascimento, Cinthia Castro do [UNIFESP]
dc.contributor.authorD'Almeida, Vania [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-07-31T12:47:48Z
dc.date.available2020-07-31T12:47:48Z
dc.date.issued2016
dc.description.abstractNon-coding RNAs (ncRNAs) are a functional class of RNA involved in the regulation of several cellular processes which may modulate disease onset, progression, and prognosis. Lysosomal storage diseases (LSD) are a group of rare disorders caused by mutations of genes encoding specific hydrolases or non-enzymatic proteins, characterized by a wide spectrum of manifestations. The alteration of ncRNA levels is well established in several human diseases such as cancer and auto-immune disordersen
dc.description.abstracthowever, there is a lack of information focused on the role of ncRNA in rare diseases. Recent reports related to changes in ncRNA expression and its consequences on LSD physiopathology show us the importance to keep advancing in this field. This article will summarize recent findings and provide key points for further studies on LSD and ncRNA association.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Lab Erros Inatos Metab, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliationUnifespLaboratório de Erros Inatos do Metabolismo, Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipInstituto de Genetica e Erros Inatos do Metabolismo (IGEIM)
dc.description.sponsorshipAssociação Fundo de Incentivo à Psicofarmacologia (AFIP)
dc.description.sponsorshipIDFAPESP: 2014/14230-0
dc.description.sponsorshipIDFAPESP: 2015/053818
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fendo.2016.00133
dc.identifier.citationFrontiers In Endocrinology. Lausanne, v. 7, p. -, 2016.
dc.identifier.doi10.3389/fendo.2016.00133
dc.identifier.fileWOS000385361700001.pdf
dc.identifier.issn1664-2392
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57100
dc.identifier.wosWOS:000385361700001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Endocrinology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectnon-coding RNAen
dc.subjectlysosomal storage diseaseen
dc.subjectlysosomeen
dc.subjectmiRNAen
dc.subjectsiRNAen
dc.titleThe Underexploited Role of Non-Coding RNAs in Lysosomal Storage Diseasesen
dc.typeinfo:eu-repo/semantics/article
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