Corpus callosum in maltreated children with posttraumatic stress disorder: A diffusion tensor imaging study

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dc.contributor.authorJackowski, Andrea P. [UNIFESP]
dc.contributor.authorDouglas-Palumberi, Heather
dc.contributor.authorJackowski, Marcel
dc.contributor.authorWin, Lawrence
dc.contributor.authorSchultz, Robert T.
dc.contributor.authorStaib, Lawrence W.
dc.contributor.authorKrystal, John H.
dc.contributor.authorKaufman, Joan
dc.contributor.institutionYale Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:49:45Z
dc.date.available2016-01-24T13:49:45Z
dc.date.issued2008-04-15
dc.description.abstractContrary to expectations derived from preclinical studies of the effects of stress, and imaging studies of adults with posttraumatic stress disorder (PTSD), there is no evidence of hippocampus atrophy in children with PTSD. Multiple pediatric studies have reported reductions in the corpus callosum - the primary white matter tract in the brain. Consequently, in the present study, diffusion tensor imaging was used to assess white matter integrity in the corpus callosum in 17 maltreated children with PTSD and 15 demographically matched normal controls. Children with PTSD had reduced fractional anisotropy in the medial and posterior corpus, a region which contains interhemispheric projections from brain structures involved in circuits that mediate the processing of emotional stimuli and various memory functions - core disturbances associated with a history of trauma. Further exploration of the effects of stress on the corpus callosum and white matter development appears a promising strategy to better understand the pathophysiology of PTSD in children. (C) 2007 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationYale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA
dc.description.affiliationYale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA
dc.description.affiliationYale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06510 USA
dc.description.affiliationUniversidade Federal de São Paulo, LiNC, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Math & Stat, BR-05508090 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, LiNC, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent256-261
dc.identifierhttp://dx.doi.org/10.1016/j.pscychresns.2007.08.006
dc.identifier.citationPsychiatry Research-neuroimaging. Clare: Elsevier B.V., v. 162, n. 3, p. 256-261, 2008.
dc.identifier.doi10.1016/j.pscychresns.2007.08.006
dc.identifier.issn0925-4927
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30600
dc.identifier.wosWOS:000255122100009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPsychiatry Research-neuroimaging
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectposttraumatic stress disorderen
dc.subjectimagingen
dc.subjectDTIen
dc.subjectChildrenen
dc.titleCorpus callosum in maltreated children with posttraumatic stress disorder: A diffusion tensor imaging studyen
dc.typeinfo:eu-repo/semantics/article
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