The chemokines secretion and the oxidative stress are targets of low-level laser therapy in allergic lung inflammation

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dc.citation.issue11/dez
dc.citation.volume9
dc.contributor.authorCarvalho, Jorge Luis Costa [UNIFESP]
dc.contributor.authorAparecida de Brito, Aurileia
dc.contributor.authorLigeiro de Oliveira, Ana Paula
dc.contributor.authorde Castro Faria Neto, Hugo Caire
dc.contributor.authorPereira, Thiago Martini
dc.contributor.authorCarvalho, Regiane Albertini de [UNIFESP]
dc.contributor.authorAnatriello, Elen [UNIFESP]
dc.contributor.authorAimbire, Flavio [UNIFESP]
dc.coverageWeinheim
dc.date.accessioned2020-07-31T12:47:06Z
dc.date.available2020-07-31T12:47:06Z
dc.date.issued2016
dc.description.abstractRecent studies show that low-level laser therapy (LLLT) has an important anti-inflammatory action in acute lung inflammation. The present work explored if laser therapy is able to antagonize eosinophils and allergic inflammation induced by oxidative stress in Balb/c mice. Forty-eight hours after challenge, the leukocyte counting, ROS and nitrite/nitrate level, RANTES, CCL3, CCL8 as well as eotaxins were measured in the bronchoalveolar lavage fluid (BALF) of laser-treated mice or not. Into the lung, some chemokines receptors, the iNOS activity and mRNA expression, and the activities of superoxide dismutase (SOD), catalase, gluthatione, NADPH oxidase activities and thiobarbituric acid reactive species (T-Bars) were measured. Laser-treated allergic mice presented reduction of both the ICAM-1 and eosinophil in the lungs. RANTES, CCL8, CCL3 and eotaxins were reduced in BALF of laser-treated allergic mice. In allergic mice lung LLLT decreased the CCR1 and CCR3 and restored the oxidative stress balance as well. Laser decreased the lipidic peroxidation in allergic mice lung as much as increased SOD, GPx and GR. It shows that LLLT on allergic lung inflammation involves leukocyte-attractant chemokines and endogenous antioxidant. Based on results, LLLT may ultimately become a non-invasive option in allergic lung disease treatment. [GRAPHICS] The top figure illustrates the laser decreasing the eosinophils migration into BALF and the bottom figure shows the laser upregulating the expression of heme-oxygenase (anti-oxidant enzyme) in lung tissue anti-oxidant.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Sci & Technol, Rua Talim,330 Vila Nair,POB 12231-280, Sao Paulo, SP, Brazil
dc.description.affiliationNove Julho Univ UNINOVE, Lab Pulm & Exercise Immunol LABPEI, Sao Paulo, SP, Brazil
dc.description.affiliationOswaldo Cruz Fdn FioCruz, Lab Immunopharmacol, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUnifespDepartment of Science and Technology, Universidade Federal de São Paulo (UNIFESP), Rua Talim, 330 – Vila Nair, PO Box 12231‐280, São José dos Campos, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent1208-1221
dc.identifierhttp://dx.doi.org/10.1002/jbio.201600061
dc.identifier.citationJournal Of Biophotonics. Weinheim, v. 9, n. 43810, p. 1208-1221, 2016.
dc.identifier.doi10.1002/jbio.201600061
dc.identifier.issn1864-063X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56593
dc.identifier.wosWOS:000392915800010
dc.language.isoeng
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofJournal Of Biophotonics
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectasthmaen
dc.subjecteosinophilsen
dc.subjectchemokinesen
dc.subjectoxidative stressen
dc.subjectphotobiomodulationen
dc.subjectlow-level laser therapyen
dc.titleThe chemokines secretion and the oxidative stress are targets of low-level laser therapy in allergic lung inflammationen
dc.typeinfo:eu-repo/semantics/article
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