Remote ischemic preconditioning and tacrolimus in the fetal small bowel transplant in mice

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dc.citation.issue10
dc.citation.volume31
dc.contributor.authorMorello, Ricardo José [UNIFESP]
dc.contributor.authorKoike, Marcia Kiyomi
dc.contributor.authorAbrahão, Marcos de Souza [UNIFESP]
dc.contributor.authorSaad, Karen Ruggeri
dc.contributor.authorSaad, Paulo Fernandes
dc.contributor.authorMontero, Edna Frasson de Souza [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-07-31T12:47:37Z
dc.date.available2020-07-31T12:47:37Z
dc.date.issued2016
dc.description.abstractPURPOSE: To evaluate the effect of remote ischemic preconditioning (IPC-R) in the fetal small bowel transplantation model. METHODS: Two groups were constituted: The Isogenic transplant (ISO, C57BL/6 mice, n=24) and the allogenic transplant (ALO, BALB/c mice, n=24). In each group, the animals were distributed with and without IPC-R. It was obtained the following subgroups: Tx, IPC-R, Fk, IPC-Fk, in both strains. Intestinal grafts were stained with hematoxylin and eosin and immunohistochemically. RESULTS: The graft development evaluation in ISO group showed that IPC-R reduced the development compared with ISO-Tx (5.2+/-0.4 vs 9.0+/-0.8) and IPC-R-Fk increased the graft development compared with IPC-R (11.2+/-0.7 and 10.2+/-0.8). In ALO group, IPC-Fk increased the development compared with ALO-Tx and ALO with IPC-R (6.0+/-0.8, 9.0+/-1.2, 0.0+/-0.0, 0.5+/-0.3). The PCNA expression was increased in ISO group treated with Fk and IPC-R compared to other groups (12.2+/-0.8 vs Tx: 8.8+/-0.9, IPC-R: 8.0+/-0.4 and Fk: 9.0+/-0.6). The graft rejection was lower in groups treated with IPC-R (-18%), Fk (-68%) or both (-61%) compared with ALO-Tx. CONCLUSION: Remote ischemic preconditioning showed benefic effect even associate with Tacrolimus on the development and acute rejection of the fetal small bowel graft in the Isogenic and Allogenic transplants.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Sch Med, Operat Tech & Expt Surg Div, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med, Lab Emergency Med LIM 51, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Vale Sao Francisco UNIVASF, Sch Med, Petrolina, PE, Brazil
dc.description.affiliationFMUSP, Surg Physiopathol Lab LIM 62, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespOperative Technique and Experimental Surgery Division, Medical School, Universidade Federal de São Paulo (UNIFESP), Brazil
dc.description.sourceWeb of Science
dc.format.extent675-679
dc.identifierhttp://dx.doi.org/10.1590/S0102-865020160100000006
dc.identifier.citationActa Cirurgica Brasileira. Sao Paulo, v. 31, n. 10, p. 675-679, 2016.
dc.identifier.doi10.1590/S0102-865020160100000006
dc.identifier.fileS0102-86502016001000675.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502016001000675
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56947
dc.identifier.wosWOS:000391432200006
dc.language.isoeng
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFetal Tissue Transplantationen
dc.subjectSmall Intestineen
dc.subjectTacrolimusen
dc.subjectIschemic Preconditioningen
dc.subjectMiceen
dc.titleRemote ischemic preconditioning and tacrolimus in the fetal small bowel transplant in miceen
dc.typeinfo:eu-repo/semantics/article
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