Postoperative rhabdomyolysis due to neuroleptic malignant syndrome associated with droperidol and metoclopramide

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dc.citation.issue4pt_BR
dc.citation.volume55pt_BR
dc.contributor.authorSilva, Helga Cristina Almeida da [UNIFESP]
dc.contributor.authorOrfali, Guilherme di Camillo [UNIFESP]
dc.contributor.authorMachado, Henrique Louzan [UNIFESP]
dc.contributor.authorAndrade, Pamela Vieira [UNIFESP]
dc.contributor.authorSantos, Joilson Moura [UNIFESP]
dc.contributor.authorSilva, Mary dos Santos [UNIFESP]
dc.contributor.authorAmaral, José Luiz Gomes do [UNIFESP]
dc.contributor.authorLatteshttp://lattes.cnpq.br/0844918862241102
dc.coverage.spatialPoland
dc.date.accessioned2024-02-15T17:21:09Z
dc.date.available2024-02-15T17:21:09Z
dc.date.issued2023-11-22
dc.description.abstractNeuroleptic malignant syndrome (NMS) is a complication of neuroleptics that can rarely occur per operatively. A female patient, 28 years old, ASA I, was admitted for bilateral mammoplasty with breast implant. During the procedure, under sedation and thoracic epidural, she received droperidol and metoclopramide. After two hours, she evolved with myalgia, tachycardia, tachypnea, hyperthermia, and increased creatine kinase (CK) levels (9,702 IU/L). After supportive therapy, there was a complete improvement. A further extensive investigation with physical/neurological examination, baseline serum CK level, and electroneuromyography was normal. Molecular study for myopathies did not detect any pathogenic variant and the in vitro muscle contracture test for malignant hyperthermia was negative. Diagnosis of exclusion of NMS was performed. The anaesthesiologist must recognize NMS manifestations, allowing early treatment.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipID001pt_BR
dc.description.sponsorshipID2021_06180-7pt_BR
dc.description.uri10.5114/ait.2023.132910
dc.format.extent304-306pt_BR
dc.identifierhttps://www.termedia.pl/Postoperative-rhabdomyolysis-due-to-neuroleptic-malignant-syndrome-associated-with-droperidol-and-metoclopramide,118,51786,1,1.htmlpt_BR
dc.identifier.citationSILVA, Helga Cristina Almeida da et al. Postoperative rhabdomyolysis due to neuroleptic malignant syndrome associated with droperidol and metoclopramide. Anaesthesiology Intensive Therapy. 2023;55(4):304-306.pt_BR
dc.identifier.doi10.5114/ait.2023.132910pt_BR
dc.identifier.issn1642-5758pt_BR
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/70718
dc.identifier.urihttps://doi.org/10.5114/ait.2023.132910
dc.languageeng
dc.publisherMirosław Czuczwar
dc.relation.ispartofAnaesthesiology Intensive Therapyen
dc.rightsAcesso abertopt_BR
dc.subjectNeuroleptic malignant syndromeen
dc.subjectAnaesthesiaen
dc.subjectDroperidolen
dc.subjectMetoclopramideen
dc.titlePostoperative rhabdomyolysis due to neuroleptic malignant syndrome associated with droperidol and metoclopramidept_BR
dc.typeArtigopt_BR
unifesp.campusEscola Paulista de Medicina (EPM)pt_BR
unifesp.departamentoCirurgiapt_BR
unifesp.graduateProgramNeurologia-Neurociênciaspt_BR
unifesp.researchAreaHipertermia malignapt_BR
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