Nerve Regeneration: Is There an Alternative to Nervous Graft?

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dc.contributor.authorSabongi, Rodrigo Guerra [UNIFESP]
dc.contributor.authorLucas Martins de Rizzo, Luiz Augusto [UNIFESP]
dc.contributor.authorFernandes, Marcela [UNIFESP]
dc.contributor.authorValente, Sandra Gomes [UNIFESP]
dc.contributor.authorGomes dos Santos, Joao Baptista [UNIFESP]
dc.contributor.authorFaloppa, Flavio [UNIFESP]
dc.contributor.authorLeite, Vilnei Mattioli [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:38:08Z
dc.date.available2016-01-24T14:38:08Z
dc.date.issued2014-11-01
dc.description.abstractBackground in nerve injury with nervous gap, no restitution method was found better than the autograft, however, it has the disadvantage of damaging a normal nerve to be used as a graft. Platelet-rich plasma (PRP) is a possible filler material for vein grafts used as conduits for nerve regeneration, preventing its collapse, and providing growth factors and osteoconductive proteins.Methods Isogenic rats were randomly divided into three groups. They received nerve autografts (GRF), PRP-containing vein grafts or a sham operation. Outcomes were evaluated by the sciatic functional index (SFI), morphometric, and morphologic analyses of the nerve distal to the lesion, and the number of spinal cord motoneurons positive for retrograde Fluoro-Gold (Santa Cruz Biotechnology, Inc., Dallas, TX) tracer.Results the PRP and GRF groups had lower SFI values than the control animals throughout the postoperative period. the SFI was significantly higher in the PRP group than the GRF group at 90 days postoperatively (p = 0.011). Fiber diameter and number of motoneurons were significantly decreased in both the PRP and GRF groups, as compared with the control.Conclusion PRP within a vein conduit may be an effective alternative or adjuvant to GRF, the current preferred treatment for nerve injury with a nerve gap, and further investigations are required to fully define the role of PRP in nerve regeneration.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Orthoped & Traumatol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Orthoped & Traumatol, Div Hand Surg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Orthoped & Traumatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Orthoped & Traumatol, Div Hand Surg, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2010/52624-0
dc.format.extent607-616
dc.identifierhttp://dx.doi.org/10.1055/s-0034-1372477
dc.identifier.citationJournal of Reconstructive Microsurgery. New York: Thieme Medical Publ Inc, v. 30, n. 9, p. 607-616, 2014.
dc.identifier.doi10.1055/s-0034-1372477
dc.identifier.issn0743-684X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38420
dc.identifier.wosWOS:000343192000003
dc.language.isoeng
dc.publisherThieme Medical Publ Inc
dc.relation.ispartofJournal of Reconstructive Microsurgery
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectnerve regenerationen
dc.subjectplatelet-rich plasmaen
dc.subjectnerve graften
dc.titleNerve Regeneration: Is There an Alternative to Nervous Graft?en
dc.typeinfo:eu-repo/semantics/article
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