Optical Coherence Tomography of Retinal Lesions in Infants With Congenital Zika Syndrome

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dc.citation.issue12
dc.citation.volume134
dc.contributor.authorVentura, Camila Vieira [UNIFESP]
dc.contributor.authorVentura, Liana O.
dc.contributor.authorBravo-Filho, Vasco
dc.contributor.authorMartins, Thayze T.
dc.contributor.authorBerrocal, Audina M.
dc.contributor.authorGois, Adriana L.
dc.contributor.authorDias, Joao Rafael de Oliveira [UNIFESP]
dc.contributor.authorAraujo, Leandro
dc.contributor.authorEscariao, Paulo
dc.contributor.authorvan der Linden, Vanessa
dc.contributor.authorBelfort, Rubens Junior [UNIFESP]
dc.contributor.authorMaia, Mauricio [UNIFESP]
dc.coverageChicago
dc.date.accessioned2020-07-31T12:47:10Z
dc.date.available2020-07-31T12:47:10Z
dc.date.issued2016
dc.description.abstractIMPORTANCE Zika virus (ZIKV) can cause severe changes in the retina and choroid that may result in marked visual impairment in infants with congenital Zika syndrome (CZS), the term created for a variety of anomalies associated with intrauterine ZIKV infection. OBJECTIVE To evaluate the affected retinal layers in infants with CZS and associated retinal abnormalities using optical coherence tomography (OCT). DESIGN, SETTING, AND PARTICIPANTS This cross-sectional, consecutive case series included 8 infants (age range, 3.0-5.1 months) with CZS. Optical coherence tomographic images were obtained in the affected eyes of 7 infants with CZS who had undergone previous ophthalmologic examinations on March 17, 2016, and in 1 infant on January 1, 2016. An IgM antibody-capture enzyme-linked immunosorbent assay for ZIKV was performed on the cerebrospinal fluid samples of 7 of the 8 infants (88%), and other congenital infections were ruled out. MAIN OUTCOMES AND MEASURES Observation of retinal and choroidal findings in the OCT images. RESULTS Among the 8 infants included in the study (3 maleen
dc.description.abstract5 femaleen
dc.description.abstractmean [SD] age at examination, 4.1 [0.7] months), 7 who underwent cerebrospinal fluid analysis for ZIKV had positive findings for IgM antibodies. Eleven of the 16 eyes (69%) of the 8 infants had retinal alterations and OCT imaging was performed in 9 (82%) of them. Optical coherence tomography was also performed in 1 unaffected eye. The main OCT findings in the affected eyes included discontinuation of the ellipsoid zone and hyperreflectivity underlying the retinal pigment epithelium in 9 eyes (100%), retinal thinning in 8 eyes (89%), choroidal thinning in 7 eyes (78%), and colobomatouslike excavation involving the neurosensory retina, retinal pigment epithelium, and choroid in 4 eyes (44%). CONCLUSIONS AND RELEVANCE Zika virus can cause severe damage to the retina, including the internal and external layers, and the choroid. The colobomatouslike finding seen in the OCT images relate to the excavated chorioretinal scar observed clinically.en
dc.description.affiliationAltino Ventura Fdn, Dept Ophthalmol, Recife, PE, Brazil
dc.description.affiliationPernambuco Eye Hosp, Dept Ophthalmol, Recife, PE, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Paulista Sch Med, Rua Botucatu 831, BR-04023062 Sao Paulo, SP, Brazil
dc.description.affiliationBascom Palmer Eye Inst, Miami, FL 33136 USA
dc.description.affiliationBarao de Lucena Hosp, Dept Pediat Neurol, Recife, PE, Brazil
dc.description.affiliationUnifespDepartment of Ophthalmology and Visual Sciences, Paulista School of Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1420-1427
dc.identifierhttp://dx.doi.org/10.1001/jamaophthalmol.2016.4283
dc.identifier.citationJama Ophthalmology. Chicago, v. 134, n. 12, p. 1420-1427, 2016.
dc.identifier.doi10.1001/jamaophthalmol.2016.4283
dc.identifier.issn2168-6165
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56624
dc.identifier.wosWOS:000390600300020
dc.language.isoeng
dc.publisherAmer Medical Assoc
dc.relation.ispartofJama Ophthalmology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleOptical Coherence Tomography of Retinal Lesions in Infants With Congenital Zika Syndromeen
dc.typeinfo:eu-repo/semantics/article
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