Use of fentanyl and midazolam in mechanically ventilated children-Does the method of infusion matter?

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dc.citation.volume32
dc.contributor.authorLucas da Silva, Paulo Sergio
dc.contributor.authorReis, Maria Eunice
dc.contributor.authorde Aguiar, Vania Euzebio
dc.contributor.authorMachado Fonseca, Marcelo Cunio [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-08-21T16:59:46Z
dc.date.available2020-08-21T16:59:46Z
dc.date.issued2016
dc.description.abstractBackground and objective: Benzodiazepines and opioids are commonly used in pediatric intensive care unit. However, there is no previous study assessing the use of administering these drugs combined (single solution) or separately. We sought to evaluate the impact of these 2 different methods of providing sedation/analgesia in pediatric intensive care unit. Methods: One hundred twelve patients mechanically ventilated for more than 48 hours were randomized to receive a protocolized sedation regimecomprising midazolamand fentanyl either separately (group 1, 57 patients) or combined as a single solution (group 2, 55 patients). Primary end point variable was the cumulated dose of midazolam and fentanyl. Results: The median cumulated doses of both fentanyl (0.19 vs 0.37 mg/kg, P < .05) and midazolam (28.8 vs 45.6 mg/kg, P < .05) required in group 2 were higher when compared with those of group 1. Moreover, group 2 patients had a significantly longer time of vasopressor drugs requirement and a higher number of patients developing tolerance. Conclusion: Patients who received a single solution of midazolam and fentanyl had a higher cumulated dose of compared with those patients who did not. The potential risk for long-term neurologic effects on developing brains associated with this finding should be considered. (C) 2015 Elsevier Inc. All rights reserved.en
dc.description.affiliationHosp Serv Publ Municipal, Dept Pediat, Pediat Intens Care Unit, Rua Castro Alves 60, BR-01532900 Sao Paulo, Brazil
dc.description.affiliationHosp & Maternidade Santa Joana, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Hlth Technol Assessment Unit, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Hlth Technol Assessment Unit, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent108-113
dc.identifierhttp://dx.doi.org/10.1016/j.jcrc.2015.12.003
dc.identifier.citationJournal Of Critical Care. Philadelphia, v. 32, p. 108-113, 2016.
dc.identifier.doi10.1016/j.jcrc.2015.12.003
dc.identifier.issn0883-9441
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57762
dc.identifier.wosWOS:000370866900021
dc.language.isoeng
dc.publisherW B Saunders Co-Elsevier Inc
dc.relation.ispartofJournal Of Critical Care
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBenzodiazepineen
dc.subjectFentanylen
dc.subjectMidazolamen
dc.subjectOpiateen
dc.subjectPediatric intensive careen
dc.subjectSedationen
dc.titleUse of fentanyl and midazolam in mechanically ventilated children-Does the method of infusion matter?en
dc.typeinfo:eu-repo/semantics/article
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