Angiotensin II or epinephrine hemodynamic and metabolic responses in the liver of L-NAME induced hypertension and spontaneous hypertensive rats

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dc.citation.issue17]
dc.citation.volume9]
dc.contributor.authorKimura, Debora Conte [UNIFESP]
dc.contributor.authorNagaoka, Márcia Regina [UNIFESP]
dc.contributor.authorBorges, Durval Rosa [UNIFESP]
dc.contributor.authorKouyoumdjian, Maria [UNIFESP]
dc.coveragePleasanton
dc.date.accessioned2020-06-26T16:30:36Z
dc.date.available2020-06-26T16:30:36Z
dc.date.issued2017
dc.description.abstractAIM To study hepatic vasoconstriction and glucose release induced by angiotensin (Ang)II or Epi in rats with pharmacological hypertension and spontaneously hypertensive rat (SHR). METHODS Isolated liver perfusion was performed following portal vein and vena cava cannulation; AngII or epinephrine (Epi) was injected in bolus and portal pressure monitored; glucose release was measured in perfusate aliquots. RESULTS The portal hypertensive response (PHR) and the glucose release induced by AngII of L-NAME were similar to normal rats (WIS). On the other hand, the PHR induced by Epi in L-NAME was higher whereas the glucose release was lower compared to WIS. Despite the similar glycogen content, glucose release induced by AngII was lower in SHR compared to Wistar-Kyoto rats although both PHR and glucose release induced by Epi in were similar. CONCLUSION AngII and Epi responses are altered in different ways in these hypertension models. Our results suggest that inhibition of NO production seems to be involved in the hepatic effects induced by Epi but not by AngII; the diminished glucose release induced by AngII in SHR is not related to glycogen content.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biochem, Expt Hepatol Lab, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, Expt Hepatol Lab, BR-11015020 Santos, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Expt Hepatol Lab, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biochem, Expt Hepatol Lab, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biosci, Expt Hepatol Lab, BR-11015020 Santos, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Med, Expt Hepatol Lab, BR-04023900 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.description.sponsorshipIDFAPESP: 2011/13974-8pt
dc.format.extent781-790
dc.identifierhttps://dx.doi.org/10.4254/wjh.v9.i17.781]
dc.identifier.citationWorld Journal Of Hepatology. Pleasanton, v. 9, n. 17, p. 781-790, 2017.
dc.identifier.doi10.4254/wjh.v9.i17.781
dc.identifier.fileWOS000404572500003.pdf
dc.identifier.issn1948-5182
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53650
dc.identifier.wosWOS:000404572500003
dc.language.isoeng
dc.publisherBaishideng Publishing Group Inc
dc.relation.ispartofWorld Journal Of Hepatology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpinephrineen
dc.subjectLiver perfusionen
dc.subjectSpontaneously hypertensive raten
dc.subjectGlucoseen
dc.subjectAngiotensin IIen
dc.subjectL-NAMEen
dc.titleAngiotensin II or epinephrine hemodynamic and metabolic responses in the liver of L-NAME induced hypertension and spontaneous hypertensive ratsen
dc.typeinfo:eu-repo/semantics/article
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