ENDOTHELIAL CELLS MAINTAIN NEURAL STEM CELLS QUIESCENT IN THEIR NICHE

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dc.citation.volume363
dc.contributor.authorAzevedo, Patrick O.
dc.contributor.authorLousado, Luiza
dc.contributor.authorPaiva, Ana E.
dc.contributor.authorAndreotti, Julia P.
dc.contributor.authorSantos, Gabryella S. P.
dc.contributor.authorSena, Isadora F. G.
dc.contributor.authorPrazeres, Pedro H. D. M.
dc.contributor.authorFilev, Renato [UNIFESP]
dc.contributor.authorMintz, Akiva
dc.contributor.authorBirbrair, Alexander
dc.coverageOxford
dc.date.accessioned2020-09-01T13:21:18Z
dc.date.available2020-09-01T13:21:18Z
dc.date.issued2017
dc.description.abstractNiches are specialized microenvironments that regulate stem cells' activity. The neural stem cell (NSC) niche defines a zone in which NSCs are retained and produce new cells of the nervous system throughout life. Understanding the signaling mechanisms by which the niche controls the NSC fate is crucial for the success of clinical applications. In a recent study, Sato and colleagues, by using state-of-the-art techniques, including sophisticated in vivo lineage-tracing technologies, provide evidence that endothelial amyloid precursor protein (APP) is an important component of the NSC niche. Strikingly, depletion of APP increased NSC proliferation in the subventricular zone, indicating that endothelial cells negatively regulate NSCs' growth. The emerging knowledge from this research will be important for the treatment of several neurological diseases. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Minas Gerais, Dept Pathol, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Lab Neurobiol, Sao Paulo, SP, Brazil
dc.description.affiliationColumbia Univ, Dept Radiol, Med Ctr, New York, NY USA
dc.description.affiliationAlbert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA
dc.description.affiliationAlbert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, Bronx, NY 10467 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Lab Neurobiol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipPro-reitoria de Pesquisa/Universidade Federal de Minas Gerais (PRPq/UFMG)
dc.description.sponsorshipNational Institute of Health
dc.description.sponsorshipAmerican Cancer Society
dc.description.sponsorshipIDNational Institute of Health: R01CA179072-01A1
dc.description.sponsorshipIDAmerican Cancer Society: 124443-MRSG-13-121-01-CDD
dc.format.extent62-65
dc.identifierhttp://dx.doi.org/10.1016/j.neuroscience.2017.08.059
dc.identifier.citationNeuroscience. Oxford, v. 363, p. 62-65, 2017.
dc.identifier.doi10.1016/j.neuroscience.2017.08.059
dc.identifier.issn0306-4522
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58180
dc.identifier.wosWOS:000413824900007
dc.language.isoeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofNeuroscience
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectneural stem cellsen
dc.subjectvascular nicheen
dc.subjectmicroenvironmenten
dc.subjectendothelial cellsen
dc.titleENDOTHELIAL CELLS MAINTAIN NEURAL STEM CELLS QUIESCENT IN THEIR NICHEen
dc.typeinfo:eu-repo/semantics/article
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