Conjunctival Impression Cytology Changes Induced by Oral Isotretinoin

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dc.contributor.authorQueiroga, Isabella Bezerra Wanderley de
dc.contributor.authorVieira, Luiz Antônio [UNIFESP]
dc.contributor.authorBarros, Jeison de Nadai [UNIFESP]
dc.contributor.authorDiniz, Margareth de Fatima Formiga Melo
dc.contributor.authorMorais, Liana Clebia Soares Lima de
dc.contributor.institutionUniv Fed Paraiba
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:05:10Z
dc.date.available2018-06-15T17:05:10Z
dc.date.issued2009-10-01
dc.description.abstractPurpose: To evaluate the bulbar conjunctiva using impression cytology in patients submitted to oral isotretinoin treatment.Methods: A prospective, cohort study was carried out in a referral ophthalmology practice at the Federal University of Paraiba and in the External Eye Disease Laboratory of the Federal University of Sao Paulo. Twenty-eight patients with acne vulgaris were selected. Impression cytology specimens collected from the temporal bulbar conjunctiva and the superior bulbar conjunctiva of both eyes before and after 3 months of oral isotretinoin treatment were assessed. The doses of isotretinoin varied from 0.35 to 0.88 mg . kg(-1) . d(-1).Results: The percentage of patients in whom impression cytology results were normal was significantly lower during oral isotretinoin treatment compared to the pretreatment phase, decreasing from 75% to 43% in the temporal bulbar conjunctiva and from 100% to 82% in the superior bulbar conjunctiva. In both regions, the parameters most affected were cell-to-cell contact, nucleus-to-cytoplasm ratio, and goblet cell density.Conclusion: Oral isotretinoin for the treatment of acne induces alterations in the conjunctival epithelium of a significant percentage of patients treated with the drug. These alterations are seen both in the exposed conjunctiva (temporal bulbar region) and in the unexposed conjunctiva (superior bulbar region).en
dc.description.affiliationUniv Fed Paraiba, Referral Ophthalmol Clin CEROF, BR-58059900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, External Dis & Cornea Serv, Paulista Med Sch, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, Ocular Dis Lab, Paulista Med Sch, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Paraiba, Dept Physiol & Pathol, BR-58059900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, External Dis & Cornea Serv, Paulista Med Sch, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, Ocular Dis Lab, Paulista Med Sch, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1009-1013
dc.identifierhttps://dx.doi.org/10.1097/ICO.0b013e3181a16858
dc.identifier.citationCornea. Philadelphia: Lippincott Williams & Wilkins, v. 28, n. 9, p. 1009-1013, 2009.
dc.identifier.doi10.1097/ICO.0b013e3181a16858
dc.identifier.issn0277-3740
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43427
dc.identifier.wosWOS:000271118400011
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofCornea
dc.rightsAcesso restrito
dc.subjectisotretinoinen
dc.subjectadverse effectsen
dc.subjecttearsen
dc.subjectkeratoconjunctivitis siccaen
dc.subjectcytologyen
dc.titleConjunctival Impression Cytology Changes Induced by Oral Isotretinoinen
dc.typeArtigo
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