White matter spectroscopy in neuromyelitis optica A case control study

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dc.contributor.authorBichuetti, Denis Bernardi [UNIFESP]
dc.contributor.authorMagalhaes Rivero, Rene Leandro [UNIFESP]
dc.contributor.authorLobato de Oliveira, Enedina Maria [UNIFESP]
dc.contributor.authorOliveira, Daniel May [UNIFESP]
dc.contributor.authorSouza, Nilton Amorin de [UNIFESP]
dc.contributor.authorNogueira, Roberto Gomes [UNIFESP]
dc.contributor.authorAbdala, Nitamar [UNIFESP]
dc.contributor.authorGabbai, Alberto Alain [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:55Z
dc.date.available2016-01-24T13:51:55Z
dc.date.issued2008-12-01
dc.description.abstractBackground Naa/Cr ratio in normal appearing white matter (NAWM) of patients with multiple sclerosis (MS) is altered beyond plaques, suggesting early axonal loss, and correlates to clinical disability. Brain lesions not typical of MS have been described in Neuromyelitis optica (NMO), and correspond to brain aquaporin-4 channel sites, but the evaluation of Naa/Cr ratio in NAWM of patients with NMO and its association to the presence of brain lesions and clinical disability have not been described. Objectives To evaluate the Naa/Cr of normal appearing white matter (NAWM) in 16 patients with NMO compared to healthy controls. Methods We performed brain magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) of 16 patients with NMO and compared to age matched healthy controls. Results NAWM Naa/Cr did not show statistical difference among patients and controls, neither between patients that had normal brain MRI and atypical brain lesions. Conclusion NAWM was found to have a normal Naa/Cr in patients with NMO, reinforcing the concept that the white matter is not primarily affected in this disease.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04039000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Radiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04039000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Radiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1895-1899
dc.identifierhttp://dx.doi.org/10.1007/s00415-009-0940-0
dc.identifier.citationJournal of Neurology. Heidelberg: Dr Dietrich Steinkopff Verlag, v. 255, n. 12, p. 1895-1899, 2008.
dc.identifier.doi10.1007/s00415-009-0940-0
dc.identifier.issn0340-5354
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31062
dc.identifier.wosWOS:000263221100005
dc.language.isoeng
dc.publisherDr Dietrich Steinkopff Verlag
dc.relation.ispartofJournal of Neurology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectwhite matteren
dc.subjectspectroscopyen
dc.subjectneuromyelitis opticaen
dc.subjectautoimmune diseaseen
dc.titleWhite matter spectroscopy in neuromyelitis optica A case control studyen
dc.typeinfo:eu-repo/semantics/article
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