The Role of PAI-1 and Adiponectin on the Inflammatory State and Energy Balance in Obese Adolescents with Metabolic Syndrome

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dc.contributor.authorCorgosinho, Flavia Campos [UNIFESP]
dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.authorSanches, Priscila de Lima [UNIFESP]
dc.contributor.authorCampos, Raquel Munhoz da Silveira [UNIFESP]
dc.contributor.authorSilva, Patricia Leao da [UNIFESP]
dc.contributor.authorCarnier, June [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorTock, Lian [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:18Z
dc.date.available2016-01-24T14:27:18Z
dc.date.issued2012-06-01
dc.description.abstractObesity is a chronic inflammatory disease and is considered a risk factor for metabolic syndrome. in this study, 57 obese adolescents with and without metabolic syndrome underwent 1 year of weight loss therapy. At baseline, the metabolic syndrome (MS) patients presented higher values of PAI-1 than the non-metabolic syndrome patients (n-MS). After therapy, significant improvements in anthropometrics and biochemical, inflammatory, and neuroendocrine variables were observed in both groups. However, the n-MS group presented better results than the MS group. Indeed, we found positive correlations in both groups between PAI-1 and neuropeptide Y (NPY) and between PAI-1 and NPY/AgRP. Inflammatory biomarkers may thus play a role in energy balance. the clinical trial registration number is NCT01358773.en
dc.description.affiliationUniversidade Federal de São Paulo, Postgrad Program Nutr, Paulista Med Sch, BR-11060001 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Post Grad Program Interdisciplinary Hlth Sci, BR-04020050 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Postgrad Program Psychobiol, Paulista Med Sch, BR-04020050 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Postgrad Program Nutr, Paulista Med Sch, BR-11060001 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Post Grad Program Interdisciplinary Hlth Sci, BR-04020050 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Postgrad Program Psychobiol, Paulista Med Sch, BR-04020050 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent944-951
dc.identifierhttps://dx.doi.org/10.1007/s10753-011-9397-2
dc.identifier.citationInflammation. New York: Springer/plenum Publishers, v. 35, n. 3, p. 944-951, 2012.
dc.identifier.doi10.1007/s10753-011-9397-2
dc.identifier.issn0360-3997
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/34943
dc.identifier.wosWOS:000303382400021
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofInflammation
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectPAI-1en
dc.subjectInterdisciplinary therapyen
dc.subjectMetabolic syndromeen
dc.subjectEnergy balanceen
dc.subjectInflammationen
dc.subjectAdolescentsen
dc.titleThe Role of PAI-1 and Adiponectin on the Inflammatory State and Energy Balance in Obese Adolescents with Metabolic Syndromeen
dc.typeinfo:eu-repo/semantics/article
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